TAILIEUCHUNG - Báo cáo sinh học: "Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5 | Genetic Vaccines and Therapy BioMed Central Research Characterization of a potent non-cytotoxic shRNA directed to the HIV-1 co-receptor CCR5 Saki Shimizu11 Masakazu Kamatat2 Panyamol Kittipongdaja1 Kevin N Chen2 Sanggu Kim2 Shen Pang3 Joshua Boyer1 F Xiao-Feng Qin4 Dong Sung An1 and Irvin SY Chen 2 Address Department of Hematology-Oncology David Geffen School of Medicine and UCLA AIDS Institute University California Los Angeles Los Angeles California 90095 USA 2Department of Microbiology Immunology and Molecular Genetics David Geffen School of Medicine and UCLA AIDS Institute University California Los Angeles Los Angeles California 90095 USA 3University of California Los Angeles Dental Research Institute and University of California Los Angeles School of Dentistry Los Angeles California 90095 USA and 4Department of Immunology University of Texas MD Anderson Cancer Center Houston Texas 77030 USA Email Saki Shimizu - sakis@ Masakazu Kamata - masa3k@ Panyamol Kittipongdaja - pamkitti@ Kevin N Chen - Sanggu Kim - sanggu@ Shen Pang - spang@ Joshua Boyer - jdelosboyer@ F Xiao-Feng Qin - fqin@ Dong Sung An - an@ Irvin SY Chen - syuchen@ Corresponding author tEqual contributors Open Access Published 10 June 2009 Received 13 February 2009 Genetic Vaccines and Therapy 2009 7 8 doi 186 1479-0556-7-8 Accepted I0 June 2009 This article is available from http content 7 1 8 2009 Shimizu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The use of shRNAs to downregulate the expression of specific genes is now relatively routine in experimentation but still hypothetical for clinical .

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