TAILIEUCHUNG - Báo cáo sinh học: " Organ distribution of transgene expression following intranasal mucosal delivery of recombinant replication-defective adenovirus gene transfer vector"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Organ distribution of transgene expression following intranasal mucosal delivery of recombinant replication-defective adenovirus gene transfer vector | Genetic Vaccines and Therapy BioMed Central Research Organ distribution of transgene expression following intranasal mucosal delivery of recombinant replication-defective adenovirus gene transfer vector Daniela Damjanovid Xizhong Zhangt Jingyu Mu Maria Fe Medina and Zhou Xing Open Access Address Department of Pathology and Molecular Medicine Centre for Gene Therapeutics and . DeGroote Institute for Infectious Disease Research McMaster University Hamilton Ontario L8N 3Z5 Canada Email Daniela Damjanovic - damjand@ Xizhong Zhang - zhangxi@ Jingyu Mu - mujin@ Maria Fe Medina - mmedina@ Zhou Xing - xingz@ Corresponding author fEqual contributors Published 8 February 2008 Received 29 March 2007 . ir J n I I 11 m M- r r Accepted 8 February 2008 Genetic Vaccines and Therapy 2008 6 5 doi 1479-0556-6-5 This article is available from http content 6 1 5 2008 Damjanovic et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract It is believed that respiratory mucosal immunization triggers more effective immune protection than parenteral immunization against respiratory infection caused by viruses and intracellular bacteria. Such understanding has led to the successful implementation of intranasal immunization in humans with a live cold-adapted flu virus vaccine. Furthermore there has been an interest in developing effective mucosal-deliverable genetic vaccines against other infectious diseases. However there is a concern that intranasally delivered recombinant viral-based vaccines may disseminate to the CNS via the olfactory tissue. Initial experimental evidence suggests that intranasally delivered recombinant adenoviral gene transfer vector may .

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