TAILIEUCHUNG - Báo cáo sinh học: "Silencing the epidermal growth factor receptor gene with RNAi may be developed as a potential therapy for non small cell lung cancer"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Silencing the epidermal growth factor receptor gene with RNAi may be developed as a potential therapy for non small cell lung cancer | Genetic Vaccines and Therapy BioMed Central Research Open Access Silencing the epidermal growth factor receptor gene with RNAi may be developed as a potential therapy for non small cell lung cancer Min Zhang1 Xin Zhang1 2 Chun-Xue Bai1 Xian-Rang Song2 Jie Chen1 Lei Gao1 Jie Hu1 Qun-Ying Hong1 Malcolm J West2 and Ming Q Wei 2 Address Department of Pulmonary Diseases Zhong Shan Hospital Fudan University Shanghai PR China and 2Department of Medicine University of Queensland Prince Charles Hospital Brisbane Australia Email Min Zhang - zhangmin712@ Xin Zhang - xinhaier@ Chun-Xue Bai - cxbai@ Xian- Rang Song - songxianrang@ Jie Chen - Lei Gao - Jie Hu - Qun-Ying Hong - Malcolm J West - Ming QWei - Corresponding author Published 30 June 2005 Received 04 April 2005 Genetic Vaccines and Therapy 2005 3 5 doi 186 1479-0556-3-5 Accepted 30 June 2005 This article is available from http content 3 1 5 2005 Zhang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Lung cancer has emerged as a leading cause of cancer death in the world. Non-small cell lung cancer NSCLC accounts for 75-80 of all lung cancers. Current therapies are ineffective thus new approaches are needed to improve the therapeutic ratio. Double stranded RNA dsRNA -mediated RNA interference RNAi has shown promise in gene silencing the potential of which in developing new methods for the therapy of NSCLC needs to be tested. We report here RNAi induced effective silencing of the epidermal growth factor receptor EGFR gene which is over expressed in NSCLC. NSCLC cell lines A549 and .

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