TAILIEUCHUNG - Báo cáo sinh học: " Regulators of kinesin involved in polarized trafficking and axon outgrowth"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Regulators of kinesin involved in polarized trafficking and axon outgrowth. | J. Biol. Journal of Biology BioMed Central Minireview Regulators of kinesin involved in polarized trafficking and axon outgrowth Shuo Luo and Michael L Nonet Address Department of Anatomy and Neurobiology Washington University School of Medicine 660 S. Euclid Avenue Saint Louis MO 63110 USA. Correspondence Michael L Nonet. Email nonetm@ Published 25 May 2006 Journal of Biology 2006 5 8 The electronic version of this article is the complete one and can be found online at http content 5 4 8 2006 BioMed Central Ltd Abstract Proteins such as UNC-76 that associate with kinesin motors are important in directing neurite extension. A small Caenorhabditis elegans coiled-coil protein UNC-69 has now been shown to interact with UNC-76 and to be involved in axonal but not dendritic transport and outgrowth as well as synapse formation. Vesicle trafficking and neurite outgrowth Neurons adopt a unique morphology that is different from other cell types in that they extend dendrites and axons from their cell bodies. The dendrites and axons serve two main purposes to connect distant cells by extending projections between the pre- and postsynaptic targets and to direct electric signal flow within neurons. Both functions require the proper outgrowth and polarization of neurites which develop into dendrites and axons. One of the common mechanisms underlying the outgrowth and polarization of developing neurites is the targeted traf-Ticking of vesicles to the growing neurite tips 1 . One source of materials needed for this growth is thought to be exocytic vesicles derived from the trans-Golgi network. These vesicles are transported to sites of growth where they fuse with the plasma membrane to deliver polarized membrane proteins to the growing neurite. In support of this idea live imaging of amyloid precursor protein APP and synaptophysin two axonal targeted proteins tagged with fluorescent proteins in cultured hippocampal neurons revealed fluorescence on vesicles .

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