TAILIEUCHUNG - Báo cáo sinh học: "Compound developmental eye disorders following inactivation of TGF signaling in neural-crest stem cells"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Compound developmental eye disorders following inactivation of TGF signaling in neural-crest stem cells. | J. Biol. Journal of Biology BioMed Central Research article Open Access Compound developmental eye disorders following inactivation of TGFp signaling in neural-crest stem cells Lars M Ittnera Heiko Wurdakat Kerstin Schwerdtfegera Thomas Kunz Fabian Ille1 Per LeveenC Tord A Hjalt Ueli SuteC Stefan Karlsson Farhad HafezH Walter Born and Lukas Sommef Addresses Research Laboratory for Calcium Metabolism Orthopedic University Hospital Balgrist CH-8008 Zurich Switzerland. Institute of Cell Biology Department of Biology ETH-Honggerberg CH-8093 Zurich Switzerland. Departments for Molecular Medicine and Gene Therapy and Department of Cell and Molecular Biology Section for Cell and Developmental Biology Lund University S-22184 Lund Sweden. IROC Institute for Refractive and Ophthalmic Surgery CH-8002 Zurich Switzerland. Current address Brain Mind Research Institute BMRI University of Sydney NSW 2050 Australia. ơThese authors contributed equally to this work. Correspondence Lukas Sommer. E-mail Received 23 May 2005 Revised 19 September 2005 Accepted 7 November 2005 Published 14 December 2005 Journal of Biology 2005 4 11 The electronic version of this article is the complete one and can be found online at http content 4 3 11 2005 Ittner et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Development of the eye depends partly on the periocular mesenchyme derived from the neural crest NC but the fate of NC cells in mammalian eye development and the signals coordinating the formation of ocular structures are poorly understood. Results Here we reveal distinct NC contributions to both anterior and posterior mesenchymal eye structures and show that TGFp signaling in these cells .

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