TAILIEUCHUNG - Báo cáo sinh học: "Transplanted astrocytes derived from BMP- or CNTF-treated glialrestricted precursors have opposite effects on recovery and allodynia after spinal cord injury"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Transplanted astrocytes derived from BMP- or CNTF-treated glialrestricted precursors have opposite effects on recovery and allodynia after spinal cord injury. | Journal of Biology BioMed Central Research article Open Access Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury Jeannette E Davies Christoph Proschel1 Ningzhe Zhang1 Mark Noble1 Margot Mayer-Proscheh and Stephen JA Davies Addresses Department of Neurosurgery Anschutz Medical Campus University of Colorado Denver 12800 East 19th Ave Aurora CO 80045 USA. f Department of Biomedical Genetics University of Rochester Medical Center 601 Elmwood Avenue Rochester NY 14642 USA. Correspondence Stephen JA Davies. Email Published 19 September 2008 Received 31 December 2007 Revised 14 June 2008 Journal of Biology 2008 7 24 doi jbiol85 Accepted 19 August 2008 The electronic version of this article is the complete one and can be found online at http content 7 7 24 2008 Davies et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Two critical challenges in developing cell-transplantation therapies for injured or diseased tissues are to identify optimal cells and harmful side effects. This is of particular concern in the case of spinal cord injury where recent studies have shown that transplanted neuroepithelial stem cells can generate pain syndromes. Results We have previously shown that astrocytes derived from glial-restricted precursor cells GRPs treated with bone morphogenetic protein-4 BMP-4 can promote robust axon regeneration and functional recovery when transplanted into rat spinal cord injuries. In contrast we now show that transplantation of GRP-derived astrocytes GDAs generated by exposure to the gp130 agonist ciliary neurotrophic factor GDAsCNTF the other .

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