TAILIEUCHUNG - Báo cáo sinh học: "A Caenorhabditis elegans genetic-interaction map wiggles into view"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: A Caenorhabditis elegans genetic-interaction map wiggles into view. | Journal of Biology BioMed Central Minireview A Caenorhabditis elegans genetic-interaction map wiggles into view Kristin C Gunsalus Address Center for Genomics and Systems Biology and Department of Biology New York University 1009 Silver Center 100 Washington Square East New York NY 10003 USA. Email kcg1@ Published 7 March 2008 Journal of Biology 2008 7 8 doi jbiol70 The electronic version of this article is the complete one and can be found online at http content 7 3 8 2008 BioMed Central Ltd Abstract Systematic mapping of genetic-interaction networks will provide an essential foundation for understanding complex genetic disorders mechanisms of genetic buffering and principles of robustness and evolvability. A recent study of signaling pathways in Caenorhabditis elegans lays the next row of bricks in this foundation. One of the enduring challenges in biology is to learn how the amazing complexity and diversity of life forms arise from a limited repertoire of heritable factors. To understand the emergent properties of biological systems it is necessary to first map the functional organization of the complex biological networks that underlie them. Many levels of function will need to be analyzed systematically to arrive at this goal. Mapping molecular interactions such as proteinprotein protein-DNA and RNA-RNA interactions will help define structural and regulatory relationships. However understanding organizational principles that determine how different parts of these networks are coordinated will require uncovering functional dependencies that may not be reflected in direct physical interactions for example between actin- and tubulin-dependent cellular processes 1 . Large-scale mapping of genetic interactions in model organisms offers a powerful approach to tackle this challenge. A recent genetic-interaction study published in Journal of Biology by Byrne et al. 2 focusing on signaling pathways of the nematode worm Caenorhabditis elegans .

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