TAILIEUCHUNG - Báo cáo sinh học: " Systematic identification of regulatory proteins critical for T -cell activation"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: Systematic identification of regulatory proteins critical for T -cell activation. | J. Biol. Journal of Biology BioMed Central Research article Open Access Systematic identification of regulatory proteins critical for T-cell activation Peter Chu Jorge Pardo Haoran Zhao Connie C Li Erlina Pali Mary M Shen Kunbin Qu Simon X Yu Betty CB Huang Peiwen Yu Esteban S Masuda Susan M Molineaux Frank Kolbinger Gregorio Aversal Jan de Vriesl Donald G Payan and X Charlene Liao Addresses Rigel Pharmaceuticals Inc. 1180 Veterans Blvd. South San Francisco CA 94080 USA. Novartis Pharma AG CH-4002 Basel Switzerland. INovartis Forschungsinstitut GmbH Brunner Strasse 59 A-1235 Vienna Austria. Current addresses Exelixis Inc. 170 Harbor Way South San Francisco CA 94083 USA. Genentech Inc. 1 DNA Way South San Francisco CA 94080 USA. These authors contributed equally to this work. Correspondence X Charlene Liao. E-mail cliao@. Donald G Payan. Email dgpayan@ Published 15 September 2003 Received 19 August 2002 Revised 3 July 2003 Journal of Biology 2003 2 21 Accepted 7 August 2003 The electronic version of this article is the complete one and can be found online at http content 2 3 21 2003 Chu et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background The activation of T cells mediated by the T-cell receptor TCR activates a battery of specific membrane-associated cytosolic and nuclear proteins. Identifying the signaling proteins downstream of TCR activation will help us to understand the regulation of immune responses and will contribute to developing therapeutic agents that target immune regulation. Results In an effort to identify novel signaling molecules specific for T-cell activation we undertook a large-scale dominant effector genetic screen using retroviral technology. We cloned and characterized 33 distinct genes from over 2 800 clones

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