TAILIEUCHUNG - Báo cáo sinh học: "The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway. | J. Biol. Journal of Biology BioMed Central Minireview The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway Barbara Stecca and Ariel Ruiz i Altaba Address The Skirball Institute New York University School of Medicine 540 First Avenue New York NY 10016 USA. Correspondence Ariel Ruiz i Altaba. E-mail ria@ Published 6 November 2002 Journal of Biology 2002 1 9 The electronic version of this article is the complete one and can be found online at http contentZI 2Z9 BioMed Central Ltd ISSN I475-4924 Abstract The discovery of small molecules that act as agonists and antagonists of the Hedgehog-Gli signaling pathway which plays important roles in the embryo and adult opens a new avenue for the treatment of diseases caused by aberrant suppression or activation of this complex pathway. The Hedgehog-Gli signaling pathway regulates numerous events during the normal development of many cell types and organs including the brain bone skin gonads lung prostate gastrointestinal tract and blood. The hedgehog hh gene - like many of the components of the signaling pathway triggered by Hedgehog Hh protein - was first identified in Drosophila where it affects pattern formation very early in embryonic development. The binding of Hh to cell membranes triggers a signaling cascade that results in the regulation of transcription by zinc-finger transcription factors of the Gli family. Of the three hh-family genes in mammals - Sonic hedgehog Shh Indian hedgehog Ihh and Desert hedgehog Dhh -Shh has been the most studied mainly because it is expressed in various tissues but also because experiments with Shh protein are generally also applicable to other members of the family. The correct regulation of the Hh-Gli signaling pathway is essential not only for normal development but also to prevent a number of human diseases associated with abnormally increased or decreased signaling. Here we discuss the potential use of small-molecule modulators of

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