TAILIEUCHUNG - Báo cáo sinh học: " Marker assisted selection with optimised contributions of the candidates to selection"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Marker assisted selection with optimised contributions of the candidates to selection | Genet. Sel. Evol. 34 2002 679-703 679 INRA EDP Sciences 2002 DOI gse 2002031 Original article Marker assisted selection with optimised contributions of the candidates to selection Beatriz VILLANUEVAa Ricardo PoNG-WONGb John A. WOOLLIAMSb a Scottish Agricultural College West Mains Road Edinburgh EH9 3JG Scotland UK b Roslin Institute Edinburgh Roslin Midlothian EH25 9PS Scotland UK Received 13 November 2001 accepted 2 August 2002 Abstract- The benefits of marker assisted selection MAS are evaluated under realistic assumptions in schemes where the genetic contributions of the candidates to selection are optimised for maximising the rate of genetic progress while restricting the accumulation of inbreeding. MAS schemes were compared with schemes where selection is directly on the QTL GAS or gene assisted selection and with schemes where genotype information is not considered PHE or phenotypic selection . A methodology for including prior information on the QTL effect in the genetic evaluation is presented and the benefits from MAS were investigated when prior information was used. The optimisation of the genetic contributions has a great impact on genetic response but the use of markers leads to only moderate extra short-term gains. Optimised PHE did as well as standard truncation GAS . with fixed contributions in the short-term and better in the long-term. The maximum accumulated benefit from MAS over PHE was at the most half of the maximum benefit achieved from GAS even with very low recombination rates between the markers and the QTL. However the use of prior information about the QTL effects can substantially increase genetic gain and when the accuracy of the priors is high enough the responses from MAS are practically as high as those obtained with direct selection on the QTL. marker assisted selection gene assisted selection optimised selection BLUP selection restricted inbreeding 1. INTRODUCTION The rapid advances in molecular genetic technologies in

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