TAILIEUCHUNG - Báo cáo khoa học: Relaxin-3⁄ insulin-like peptide 7, a neuropeptide involved in the stress response and food intake Masaki Tanaka

Relaxin-3, also known as insulin-like peptide-7, is a newly-identified peptide of the insulin superfamily. All members of this superfamily have a similar structure, which consists of two subunits (A-chain and B-chain) linked by disulfide bonds. Relaxin-3 is so named because it has a motif that can interact with the relaxin receptor. | IFEBS Journal MINIREVIEW Relaxin-3 insulin-like peptide 7 a neuropeptide involved in the stress response and food intake Masaki Tanaka Department of Basic Geriatrics Kyoto PrefecturalUniversity of Medicine Japan Keywords food intake gene expression hypothalamus nucleus incertus RXFP3 stress Correspondence M. Tanaka Department of Basic Geriatrics Kyoto PrefecturalUniversity of Medicine Kawaramachi-Hirokoji Kamikyo-ku Kyoto 602-8566 Japan Fax 81 75 251 5797 Tel 81 75 251 5797 E-mail mtanaka@ Received 13 June 2010 revised 26 August 2010 accepted 18 October 2010 doi Relaxin-3 also known as insulin-like peptide-7 is a newly-identified peptide of the insulin superfamily. All members of this superfamily have a similar structure which consists of two subunits A-chain and B-chain linked by disulfide bonds. Relaxin-3 is so named because it has a motif that can interact with the relaxin receptor. By contrast to other relaxins relaxin-3 is mainly expressed in the brain and testis. In rodent brain anatomical studies have revealed its predominant expression in neurons of the nucleus incertus of the dorsal pons and a few other regions of the brainstem. On the other hand relaxin-3-expressing nerve fibers and the relaxin-3 receptors RXFP3 and RXFP1 are widely distributed in the forebrain with the hypothalamus being one of the most densely-innervated regions. Therefore relaxin-3 is considered to exert various actions through its ligand-receptor system. This minireview describes the expression of relaxin-3 in the brain as well as its functions in the hypothalamus including the stress response and food intake. Introduction Relaxin-3 insulin-like peptide-7 INSL7 has recently been identified as a new member of the insulin relaxin family using human genomic databases 1 . The 142 amino acid human precursor polypeptide sequence is well conserved among humans pigs rats and mice 2 . Structurally this precursor polypeptide consists of signal .

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