TAILIEUCHUNG - Báo cáo khoa học: Expression of cholinesterases in human kidney and its variation in renal cell carcinoma types

Despite the aberrant expression of cholinesterases in tumours, the question of their possible contribution to tumorigenesis remains unsolved. The identifica-tion in kidney of a cholinergic system has paved the way to functional studies, but details on renal cholinesterases are still lacking. To fill the gap and to determine whether cholinesterases are abnormally expressed in renal tumours, paired pieces of normal kidney and renal cell carcinomas (RCCs) were compared for cholinesterase activity and mRNA levels | Expression of cholinesterases in human kidney and its variation in renal cell carcinoma types Encarnacion Munoz-Delgado1 Maria Fernanda Montenegro1 Francisco Javier Campoy1 Maria Teresa Moral-Naranjo1 Juan Cabezas-Herrera2 Gyula Kovacs3 and Cecilio J. Vidal1 1 Department of Biochemistry and Molecular Biology-A University of Murcia Spain 2 Research Unit of Clinical Analysis Service University HospitalVirgen de la Arrixaca Murcia Spain 3 Laboratory of Molecular Oncology MedicalFaculty Ruprecht-Karls-University of Heidelberg Germany Keywords chromophobe renalcellcarcinoma chRCC conventionalrenalcellcarcinoma cRCC glycosylphosphatidylinositolanchor papillary renalcellcarcinoma pRCC renal oncocytoma Correspondence C. J. Vidal Department of Biochemistry and Molecular Biology-A University of Murcia Campus de Espinardo E-30071 Murcia Spain Fax 34 868 884147 Tel 34 868 884774 E-mail cevidal@ Received 9 July 2010 revised 10 August 2010 accepted 3 September 2010 doi Despite the aberrant expression of cholinesterases in tumours the question of their possible contribution to tumorigenesis remains unsolved. The identification in kidney of a cholinergic system has paved the way to functional studies but details on renal cholinesterases are still lacking. To fill the gap and to determine whether cholinesterases are abnormally expressed in renal tumours paired pieces of normal kidney and renal cell carcinomas RCCs were compared for cholinesterase activity and mRNA levels. In studies with papillary RCC pRCC conventional RCC chromophobe RCC and renal oncocytoma acetylcholinesterase activity increased in pRCC mU-mg 1 P and conventional RCC mU-mg 1 P with respect to their controls and mU-mg 1 . Butyrylcholinesterase activity increased in pRCC versus mU-mg 1 P . Glycosylphosphatidylinositol-linked acetylcholinesterase dimers and hydrophilic butyrylcholinesterase tetramers

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