TAILIEUCHUNG - Báo cáo khoa học: Peroxisomes as dynamic organelles: peroxisomal matrix protein import

The heterogeneity of peroxisomal matrix proteins which are imported in a folded, even oligomeric state, requires adaptive and dynamic properties of the translocation machinery. Dynamic multicompartmental subcellular dis-tribution of peroxisomal proteins is governed by the accessibility of target-ing signals. Conformational changes of peroxisomal targeting receptors upon cargo-binding might serve as a docking ‘quality control’. | MINIREVIEW Peroxisomes as dynamic organelles peroxisomal matrix protein import Janina Wolf Wolfgang Schliebs and Ralf Erdmann Institut fur Physiologische Chemie Medizinische Fakultat Ruhr-Universitat Bochum Germany Keywords peroxins peroxisome biogenesis peroxisomes PEX protein import Correspondence R. Erdmann Institut fur Physiologische Chemie Medizinische Fakultat Ruhr-Universitat Bochum UniversitatsstraBe 150 44780 Bochum Germany Fax 0049 3214266 Tel 0049 234 3224943 E-mail Received 19 February 2010 revised 12 May 2010 accepted 15 June 2010 doi The heterogeneity of peroxisomal matrix proteins which are imported in a folded even oligomeric state requires adaptive and dynamic properties of the translocation machinery. Dynamic multicompartmental subcellular distribution of peroxisomal proteins is governed by the accessibility of targeting signals. Conformational changes of peroxisomal targeting receptors upon cargo-binding might serve as a docking quality control . Although the mechanisms are not understood in detail recent work suggests the existence of a transient translocon within the peroxisomal membrane. Rapid formation and disassembly of the transient import pore ensures the integrity of the peroxisomal membrane barrier for small metabolites. In this review we will focus on the regulatory aspects of peroxisomal matrix protein import. Introduction Peroxisomes constitute a ubiquitous family of cell organelles also known as microbodies which were first described in 1954 by Rhodin 1 and also comprise plant and fungal glyoxysomes glycosomes of kineto-plastidae as well as Woronin bodies of filamentous fungi. The typical presence of hydrogen peroxide H2O2 -producing oxidases and H2O2-decomposing catalase were eponymous for their designation as peroxisomes 2 . To date more than 50 peroxisomal enzymes with various anabolic and catabolic functions have been identified for an overview see the peroxisome database http

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