TAILIEUCHUNG - Báo cáo " Concise report on study of proteinase inhibitors and their utilization in practice (from 1986 – July 2007) "

Proteinase inhibitors (PIs) are widely distributed in plants, microorganisms and mammalian species; they are known to play pivotal roles in regulating proteinase activities in these species. Accordingly, PIs are important molecular tools for many research disciplines. Studies of the correlation of PI structures and functions have lead to understanding of their inhibitory actions against physiological important proteases. There are potential therapeutic applications for such studies for diseases relating to excessive activities of proteases. Our studies on PIs in Viet nam have been begun since 1986, focusing on the following topics:. | Tạp chí Khoa học ĐHQGHN Khoa học Tự nhiên và Công nghệ 23 2007 223-230 Concise report on study of proteinase inhibitors and their utilization in practice from 1986 - July 2007 Pham Thi Tran Chau Institute of Microbiology and Biotechnology VNU 144 Xuan Thuy Hanoi Vietnam Received 12 December 2007 Abstract. Proteinase inhibitors PIs are widely distributed in plants microorganisms and mammalian species they are known to play pivotal roles in regulating proteinase activities in these species. Accordingly PIs are important molecular tools for many research disciplines. Studies of the correlation of PI structures and functions have lead to understanding of their inhibitory actions against physiological important proteases. There are potential therapeutic applications for such studies for diseases relating to excessive activities of proteases. Our studies on PIs in Viet nam have been begun since 1986 focusing on the following topics Quantitative analysis of proteinase inhibitory activity PIA in wild type and cultivated plants tracing of PIs in the process of seed development and the distribution of PIs in different parts of seed establishment of the procedure for isolation of the selected PIs the procedure for using PIs preparations in medical and agricultural practice characterization of the isolated PIs study of their structure investigation of their potential therapeutic and agricultural applications clinical trial studies for the selected PIs preparations. This paper is a brief summary of our 56 works published in the national and international journals as well as at the symposia and conferences . Keywords proteinase inhibitors Momordica cochinchinensis anti-inflamation anti-bacterial activity insecticide. 1. Introduction Proteases are widely found in plants and animals as well as in microorganisms. It is reported that 2 of all gene products are proteases Barret et all 1998 . They play a crucial role in the physiology and pathology of living organisms by controlling .

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