TAILIEUCHUNG - Báo cáo khoa học: Natriuretic peptide metabolism, clearance and degradation

Atrial natriuretic peptide, B-type natriuretic peptide and C-type natriuretic peptide constitute a family of three structurally related, but genetically dis-tinct, signaling molecules that regulate the cardiovascular, skeletal, nervous, reproductive and other systems by activating transmembrane guanylyl cyc-lases and elevating intracellular cGMP concentrations. | ịFEBS Journal MINIREVIEW Natriuretic peptide metabolism clearance and degradation Lincoln R. Potter Department of Biochemistry Molecular Biology and Biophysics University of Minnesota-Twin Cities Minneapolis MN USA Keywords ANF atrialnatriuretic peptide ANP B-type natriuretic peptide BNP cardiovascular disease cGMP endochondrialossification neprilysin proteolysis receptor internalization Correspondence L. R. Potter Department of Biochemistry Molecular Biology and Biophysics University of Minnesota-Twin Cities 6-155 Jackson Hall 321 Church Street SE Minneapolis MN 55455 USA Fax 1 612 624 7282 Tel 1 612 624 7251 E-mail potter@ Received 13 September 2010 revised 16 December 2010 accepted 4 February 2011 doi Atrial natriuretic peptide B-type natriuretic peptide and C-type natriuretic peptide constitute a family of three structurally related but genetically distinct signaling molecules that regulate the cardiovascular skeletal nervous reproductive and other systems by activating transmembrane guanylyl cyclases and elevating intracellular cGMP concentrations. This review broadly discusses the general characteristics of natriuretic peptides and their cognate signaling receptors and then specifically discusses the tissue-specific metabolism of natriuretic peptides and their degradation by neprilysin insulin-degrading enzyme and natriuretic peptide receptor-C. Introduction General characteristics of natriuretic peptides and their receptors All natriuretic peptides are synthesized as preprohor-mones that are processed to smaller mature forms containing an obligate C-terminal 17-residue disulfide ring structure. More detailed reviews of natriuretic peptides and their receptors are given in other articles in this series 1-3 . Atrial natriuretic peptide ANP is primarily stored as a propeptide in atrial granules and is secreted and cleaved to a 28-residue mature peptide as it enters the circulation in response to atrial stretch. A version

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