TAILIEUCHUNG - báo cáo khoa học: " Randomized, placebo-controlled, double-blind trial of Swedish snus for smoking reduction and cessation"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Randomized, placebo-controlled, double-blind trial of Swedish snus for smoking reduction and cessation | Joksic et al. Harm Reduction Journal 2011 8 25 http content 8 1 25 HARM REDUCTION JOURNAL RESEARCH Open Access Randomized placebo-controlled double-blind trial of Swedish snus for smoking reduction and cessation 1 1 2 2 3 Gordana Joksic Vera Spasojevic-Tisma Ruza Antic Robert Nilsson and Lars E Rutqvist Abstract Background Epidemiological studies suggest that smokeless tobacco in the form of Swedish snus has been used by many smokers in Scandinavia to quit smoking but the efficacy of snus has so far not been evaluated in controlled clinical trials. Methods We conducted a randomized double-blind placebo-controlled clinical trial aimed at assessing the efficacy of snus to help adult cigarette smokers in Serbia to substantially reduce and eventually completely stop smoking. The study enrolled 319 healthy smokers aged 20-65 years at two occupational health centers in Belgrade Serbia. Most of them 81 expressed an interest to quit rather than just reduce their smoking. Study products were used ad libitum throughout the 48-week study period. The main study objective during the first 24 weeks was smoking reduction. The primary end-point was defined as a biologically verified reduction of 50 in the average number of smoked cigarettes per day during week 21-24 compared to baseline. During week 25-48 participants were actively instructed to stop smoking completely. Outcome measures of biologically verified complete smoking cessation included 1-week point prevalence rates at clinical visits after 12 24 36 and 48 weeks as well as 4- 12- and 24-week continued cessation rates at the week 36 and 48 visits. Results At the week 24 visit the proportion of participants who achieved the protocol definition of a 50 smoking reduction was similar in the two treatment groups. However the proportion that reported more extreme reductions 75 was statistically significantly higher in the snus group than in the placebo group p . The results for biologically .

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