TAILIEUCHUNG - Tho Huu Le, Thinh Quang Bui, Phu Hoang Dang, Hai Xuan Nguyen, Truong Nhat Van Do

The present study investigated the phytochemical and biological properties of the rhizomes C. aromatica. From the CHCl3 extract of C. aromatic rhizomes, six known compounds, including (-)-hannokinol, (3R,5R)-3,5-diacetoxy-1,7-bis(4- hydroxyphenyl)heptane, naringenin, 2-(4- (hydroxymethyl)phenyl)propan-2-ol, 5-hydroxymethylfurfural, and bisacurone, were isolated. All compounds were tested on the biological inhibitory activities against tyrosinase, αglucosidase, and urease. It was the first time all compounds were isolated from rhizomes of C. aromatica Salisb. | Cite this paper Vietnam J. Chem. 2023 61 S2 60-65 Research Article DOI Chemical properties and inhibitory activities of tyrosinase α-glucosidase and urease from chloroform extract of Curcuma aromatica Salisb. rhizomes Tho Huu Le1 2 3 Thinh Quang Bui1 2 Phu Hoang Dang1 2 3 Hai Xuan Nguyen1 2 3 Truong Nhat Van Do1 2 3 Mai Thanh Thi Nguyen1 2 3 Nhan Trung Nguyen1 2 3 1 Faculty of Chemistry University of Science 227 Nguyen Van Cu Road District 5 Ho Chi Minh City 70000 Viet Nam 2 Vietnam National University of Ho Chi Minh City Vo Truong Toan Road Linh Trung district Thu Duc City Ho Chi Minh City 70000 Viet Nam 3 Research Lab for Drug Discovery and Development University of Science 227 Nguyen Van Cu Road District 5 Ho Chi Minh City 70000 Viet Nam Submitted February 18 2023 Revised April 13 2023 Accepted April 24 2023 Abstract quot Nghệ trắng quot has the scientific name of Curcuma aromatica Salisb. belongs to the Ginger family Zingiberaceae and its rhizomes are used to prevent aging anti-inflammatory and improve skin. From the chloroform extract of C. aromatica six known compounds including - -hannokinol 1 3R 5R -3 5-diacetoxy-1 7-bis 4-hydroxyphenyl heptane 2 naringenin 3 2- 4- hydroxymethyl phenyl propan-2-ol 4 5-hydroxymethylfurfural 5 and bisacurone 6 were isolated. Structures of all compounds were elucidated by analyzing NMR data together with comparing them to references. All isolated compounds were found for the first time in the C. aromatia rhizomes grown in Vietnam. The results of bioactivity evaluation showed that naringenin 3 has an effect against tyrosinase and α-glucosidase with the IC50 values of and µM respectively. - -Hannokinol 1 is a moderate bioactivity ingredient capable to inhibiting α-glucosidase and urease with the IC50 value of and µM respectively. Consequently these results suggest that chloroform extract of C. aromatica may be a practical therapeutic approach for diabetes melanogenesis and stomach .

• Vật lý
• Curcuma aromatica
• Nghệ trắng
• Anticancer activities
• Biological inhibitory
• Inhibiting α glucosidase
• Anti inflammatory
• Benzyl adenine in curcuma aromatica salisb
• Sucrose for in vitro microrhizome production in curcuma aromatica salisb
• Curcuma aromatica salisb
• In vitro microrhizome production
• Tuber diameter reached
• Sanger sequencing
• High performance liquid chromatography
• Potential anticancer components
• Identification of curcuma aromatica growing
• Crown gall inhibition
• Curcuma zedoaria
• Qualitative assay
• Quantitative assay
• Antimicrobial activity
• In vitro culture
• Micropropagation protocol
• Minimum inhibitory concentration
• Kháng oxy hóa
• Cao chiết ethanol thân rễ Ngải tím
• Zingiber zerumbet Sm
• Phương pháp DPPH
• Tạp chí y học
• Chuyên đề dược
• Dược liệu ngải trắng
• Thân rễ cây ngải trắng
• Thành phần hóa học ngải trắng
• Bài viết về y tế
• Bào chế viên nang mềm ngải trắng
• Viên nang mềm
• Phương pháp HPLC
• Tạp chí Khoa học
• Công nghệ Sinh học
• Hoạt tính kháng oxy hóa
• Cao chiết nghệ trắng
• Năng lực khử sắt của Nghệ trắng
• Nghiên cứu Y học
• Khoa học Dược
• Cao khô sấy phun
• Viên nén Ngải trắng
• Xơ vữa tim mạch
• Luận văn Thạc sĩ
• Luận văn Thạc sĩ Sinh học
• Ức chế tế bào ung thư vú
• Cao chiết cây ngải trắng
• Phản ứng Real time PCR
• Dịch chiết Nghệ trắng
• Hoạt tính sinh học dịch chiết Nghệ trắng
• Nghệ trắng tại Yên Bái
• Tính oxi hóa của Nghệ trắng
• Công dụng của Nghệ trắng
• Tạp chí Khoa học Công nghệ Việt Nam