TAILIEUCHUNG - Chapter 140. Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria (Part 4)

Chryseobacterium Species (Formerly Flavobacterium) C. meningosepticum is an important cause of nosocomial infections, including outbreaks due to contaminated fluids (., disinfectants and aerosolized antibiotics) and sporadic infections due to indwelling devices, feeding tubes, and other fluid-associated apparatuses. Patients with nosocomial C. meningosepticum infection usually have underlying immunosuppression (., related to malignancy). C. meningosepticum has been reported to cause meningitis (primarily in neonates), sepsis, endocarditis, bacteremia, soft tissue infections, and pneumonia. C. indologenes has caused bacteremia, sepsis, and pneumonia, typically in immunocompromised patients with indwelling devices. . | Chapter 140. Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria Part 4 Chryseobacterium Species Formerly Flavobacterium C. meningosepticum is an important cause of nosocomial infections including outbreaks due to contaminated fluids . disinfectants and aerosolized antibiotics and sporadic infections due to indwelling devices feeding tubes and other fluid-associated apparatuses. Patients with nosocomial C. meningosepticum infection usually have underlying immunosuppression . related to malignancy . C. meningosepticum has been reported to cause meningitis primarily in neonates sepsis endocarditis bacteremia soft tissue infections and pneumonia. C. indologenes has caused bacteremia sepsis and pneumonia typically in immunocompromised patients with indwelling devices. Chryseobacterium Infections Treatment Chryseobacteria are often susceptible to fluoroquinolones TMP-SMX imipenem and third- or fourth-generation cephalosporins but susceptibility testing should be performed. Pasteurella multocida P. multocida is a bipolar-staining gram-negative coccobacillus that colonizes the respiratory and gastrointestinal tracts of domestic animals oropharyngeal colonization rates are 70-90 in cats and 50-65 in dogs. P. multocida can be transmitted to humans through bites or scratches via the respiratory tract from contact with contaminated dust or infectious droplets or via deposition of the organism on injured skin or mucosal surfaces during licking. Most human infections affect skin and soft tissue almost two-thirds of these infections are caused by cats. Patients at the extremes of age or with serious underlying disorders . cirrhosis are at increased risk for systemic manifestations including meningitis peritonitis osteomyelitis endocarditis and septic shock but cases have also occurred in healthy individuals. If inhaled P. multocida can cause acute respiratory tract infection particularly in patients with underlying sinus and pulmonary disease. .

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