TAILIEUCHUNG - Variable roles of interleukin-17F in different cancers

Interleukin (IL)-17 family is a group of six cytokines that plays a central role in inflammatory processes and participates in cancer progression. Interleukin-17A has been shown to have mainly a protumorigenic role, but the other members of the IL-17 family, including IL-17F, have received less attention. | Mikkola et al. BMC Cancer 2022 22 54 https s12885-021-08969-0 RESEARCH Open Access Variable roles of interleukin-17F in different cancers Tiina Mikkola1 2 Rabeia Almahmoudi1 2 Tuula Salo1 2 3 4 5 and Ahmed Al-Samadi1 2 Abstract Background Interleukin IL -17 family is a group of six cytokines that plays a central role in inflammatory processes and participates in cancer progression. Interleukin-17A has been shown to have mainly a protumorigenic role but the other members of the IL-17 family including IL-17F have received less attention. Methods We applied systematic review guidelines to study the role of IL-17F protein and mRNA expression polymorphisms and functions in cancer. We carried out a systematic search in PubMed Ovid Medline Scopus and Cochrane libraries yielding 79 articles that met the inclusion criteria. Results The findings indicated that IL-17F has both anti- and protumorigenic roles which depend on cancer type and the molecular form and location of IL-17F. As an example the presence of IL-17F protein in tumor tissue and patient serum has a protective role in oral and pancreatic cancers whereas it is protumorigenic in prostate and bladder cancers. These effects are proposed to be based on multiple mechanisms such as inhibition of angiogenesis vasculogenic mimicry and cancer cell proliferation migration and invasion and aggravating the inflammatory process. No solid evidence emerged for the correlation between IL-17F polymorphisms and cancer incidence or patients prognosis. Conclusion IL-17F is a multifaceted cytokine. There is a clear demand for more well-designed studies of IL-17F to elucidate its molecular mechanisms in different types of cancer. The studies presented in this article examined a variety of different designs study populations and primary secondary outcomes which unfortunately reduces the value of direct interstudy comparisons. Keywords IL-17F cancer Systematic review Lymphocytes Prognostic Polymorphism Introduction .

• Y khoa - Dược
• BMC Cancer
• Systematic review
• Cancer progression
• Interleukin 17 family
• Inflammatory processes
• Protumorigenic role
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Breast cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study