TAILIEUCHUNG - Optimizing the treatment mode for de novo metastatic nasopharyngeal carcinoma with bone-only metastasis

No standard radiotherapy regimens have been established for the treatment of de novo metastatic nasopharyngeal carcinoma (mNPC) with bone-only metastasis. The current study aimed to investigate the efficacy of palliative chemotherapy (PCT) plus locoregional radiotherapy (LRRT) with or without local radiotherapy (RT) for metastatic bone lesions in mNPC. | Lin et al. BMC Cancer 2022 22 35 https s12885-021-09152-1 RESEARCH Open Access Optimizing the treatment mode for de novo metastatic nasopharyngeal carcinoma with bone-only metastasis Cheng Lin1 Sheng Lin2 Lili Zhu3 Shaojun Lin1 Jianji Pan1 and Yun Xu1 Abstract Background No standard radiotherapy regimens have been established for the treatment of de novo metastatic nasopharyngeal carcinoma mNPC with bone-only metastasis. The current study aimed to investigate the efficacy of palliative chemotherapy PCT plus locoregional radiotherapy LRRT with or without local radiotherapy RT for metastatic bone lesions in mNPC. Methods We retrospectively analysed 131 de novo patients with mNPC who had bone-only metastasis and received at least two cycles of PCT with LRRT. The difference in survival was evaluated by the log-rank test. Univariable and multivariable analyses were performed by Cox regression. Results The median overall survival OS and progression-free survival PFS were months and months respectively. Patients with five or fewer metastatic bone lesions had significantly longer OS months vs. months Hazard ratios HR p Lin et al. BMC Cancer 2022 22 35 Page 2 of 9 To date mNPC is generally considered an incurable dis- pathological diagnosis. Restaging of all patients was ease and there is no optimal treatment. Palliative chemo- performed according to the 8th edition of the American therapy PCT is the primary treatment and locoregional Joint Committee on Cancer AJCC Union for Interna- radiation therapy LRRT is strongly recommended tional Cancer Control UICC . Our study was approved in chemotherapy-sensitive patients with mNPC 4 5 . by the Ethics Committee of Fujian Medical University Radiotherapy RT to metastatic bones is only widely Cancer Hospital Fuzhou China. Written informed con- administered for relieving pain and improving quality of sent was obtained from all patients. life in patients with de novo mNPC who have bone-only .

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• BMC Cancer
• Palliative chemotherapy
• Locoregional radiation therapy
• Chemotherapy regimens
• Including gemcitabine
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Breast cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study