TAILIEUCHUNG - Eribulin improved the overall survival from the initiation of first-line chemotherapy for HER2-negative advanced breast cancer: A multicenter retrospective study

Eribulin methylate (eribulin) improved the overall survival (OS) of eribulin-treated patients with HER2- negative advanced breast cancer (ABC) in prospective and retrospective studies. However, the effect of eribulin on OS as first-line chemotherapy and the characteristics of the patients who benefited from eribulin remain unclear. | Nakamoto et al. BMC Cancer 2022 22 31 https s12885-021-09137-0 RESEARCH ARTICLE Open Access Eribulin improved the overall survival from the initiation of first-line chemotherapy for HER2-negative advanced breast cancer a multicenter retrospective study Shogo Nakamoto1 2 Junichiro Watanabe1 Shoichiro Ohtani3 Satoshi Morita4 and Masahiko Ikeda2 Abstract Background Eribulin methylate eribulin improved the overall survival OS of eribulin-treated patients with HER2- negative advanced breast cancer ABC in prospective and retrospective studies. However the effect of eribulin on OS as first-line chemotherapy and the characteristics of the patients who benefited from eribulin remain unclear. Methods Between January 2011 and December 2016 301 patients with HER2-negative ABC who started first-line chemotherapy at 3 institutions were retrospectively evaluated for OS from the initiation of first-line chemotherapy. Results We identified 172 patients 119 estrogen receptor-positive ER 47 ER 6 unknown who received eribulin eribulin group and 129 patients 92 ER 31 ER 6 unknown who did not receive eribulin non-eribulin group . The median OS from the initiation of first-line chemotherapy in the two groups was not statistically significant 869 vs. 744 days P log-rank however in patients who received eribulin in later lines 3rd-line and who had a history of perioperative chemotherapy with anthracycline- and or taxane-based regimens the median OS improved 1001 vs. 744 days P and 834 vs. 464 days respectively P respectively Wilcoxon . Multivariate analyses revealed that a history of perioperative chemotherapy with anthracycline- and or taxane-based regimens was a pre- dictive factor hazard ratio 95 confidence interval for OS. Conclusions This study successfully identified subgroups of HER2 ABC patients with improved OS by eribulin therapy. Selecting patients according to their background and line of treatment will maximize the efficacy of .

• Y khoa - Dược
• BMC Cancer
• Advanced breast cancer
• HER2 negative
• Overall survival
• Real world
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Breast cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study