TAILIEUCHUNG - Assessing frequency and clinical outcomes of BRCA mutated ovarian cancer in Saudi women

BRCA gene mutations (BRCAm) have an impact on patients’ characteristics and clinical outcomes of ovarian cancer (OC). The frequency and patterns of BRCAm vary among countries and ethnicities. There are limited data from Saudi Arabia (SA); thus, this study aims to determine the frequency, pattern, and impact on patient characteristics and outcomes of BRCAm OC compared to wild-type BRCA (BRCAw) in Saudi women. | Agha et al. BMC Cancer 2022 22 18 https s12885-021-09123-6 RESEARCH ARTICLE Open Access Assessing frequency and clinical outcomes of BRCA mutated ovarian cancer in Saudi women Naela Agha1 2 Bader Alshamsan1 3 Sharifa Al Farsi4 Heba Aly Ateya1 5 Fahad A. Almugbel1 Hazem Abdullah Alotaibi1 6 Ayman Omar1 7 Amgad Shahin Mohamed1 5 Hanan Alharthy1 8 Tusneem Elhassan1 Hany Salem4 and Hamed Alhusaini1 Abstract Purpose BRCA gene mutations BRCAm have an impact on patients characteristics and clinical outcomes of ovarian cancer OC . The frequency and patterns of BRCAm vary among countries and ethnicities. There are limited data from Saudi Arabia SA thus this study aims to determine the frequency pattern and impact on patient characteristics and outcomes of BRCAm OC compared to wild-type BRCA BRCAw in Saudi women. Methods This retrospective study evaluated women diagnosed with non-mucinous OC fallopian tube or peritoneal carcinoma who had BRCA status tested in an accredited lab between January 2016 and December 2017. The associa tions between various parameters and BRCAm were estimated using logistic regression. Statistical analysis performed with SPSS Version 27 . Result Sixty-one women with a median age of 52 at diagnosis were analyzed. Germline BRCA mutations were found in 41 of cases 25 61 . The most common deleterious germline BRCA1 mutation was 39 . Most women 72 had no family history of cancers and 82 had advanced stage. Regardless of BRCA mutations an opti mal overall response rate ORR to first-line treatment has been achieved although most cases relapsed 84 and the majority were platinum-sensitive relapse 85 . Higher ORR to subsequent lines and better survival were obtained in women with BRCA -mutation. Conclusion The prevalence of BRCAm of OC was higher in Saudi women compared to regional and most of the international figures. The better clinical outcomes of BRCAm women agreed with the reported evidence. Further stud ies on BRCA mutations

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• BMC Cancer
• Ovarian cancer
• BRCA mutation
• Founder mutation
• Clinical outcomes
• Platinum sensitive relapse
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Breast cancer
• Prostate cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study