TAILIEUCHUNG - Angiogenesis-related lncRNAs predict the prognosis signature of stomach adenocarcinoma

Stomach adenocarcinoma (STAD), which accounts for approximately 95% of gastric cancer types, is a malignancy cancer with high morbidity and mortality. Tumor angiogenesis plays important roles in the progression and pathogenesis of STAD, in which long noncoding RNAs (lncRNAs) have been verified to be crucial for angiogenesis. | Han et al. BMC Cancer 2021 21 1312 https s12885-021-08987-y RESEARCH Open Access Angiogenesis-related lncRNAs predict the prognosis signature of stomach adenocarcinoma Chen Han Cong Zhang Huixia Wang Kexin Li and Lianmei Zhao Abstract Background Stomach adenocarcinoma STAD which accounts for approximately 95 of gastric cancer types is a malignancy cancer with high morbidity and mortality. Tumor angiogenesis plays important roles in the progression and pathogenesis of STAD in which long noncoding RNAs lncRNAs have been verified to be crucial for angiogenesis. Our study sought to construct a prognostic signature of angiogenesis-related lncRNAs ARLncs to accurately predict the survival time of STAD. Methods The RNA-sequencing dataset and corresponding clinical data of STAD were acquired from The Cancer Genome Atlas TCGA . ARLnc sets were obtained from the Ensemble genome database and Molecular Signatures Database MSigDB Angiogenesis M14493 INTegrin pathway M160 . A ARLnc-related prognostic signature was then constructed via univariate Cox and multivariate Cox regression analysis in the training cohort. Survival analysis and Cox regression were performed to assess the performance of the prognostic signature between low- and high-risk groups which was validated in the validation cohort. Furthermore a nomogram that combined the clinical patho- logical characteristics and risk score conducted to predict the overall survival OS of STAD. In addition ARLnc-mRNA coexpression pairs were constructed with Pearson s correlation analysis and visualized to infer the functional annota- tion of the ARLncs by gene ontology GO and Kyoto Encyclopedia of Genes and Genomes KEGG pathway analysis. The expression of four ARLncs in STAD and their correlation with the angiogenesis markers CD34 and CD105 were also validated by RT qPCR in a clinical cohort. Results A prognostic prediction signature including four ARLncs PVT1 LINC01315 and was identified and

• Y khoa - Dược
• BMC Cancer
• Stomach adenocarcinoma
• Long noncoding RNA
• Stomach adenocarcinoma
• Gastric cancer types
• Malignancy cancer
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Breast cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study