TAILIEUCHUNG - Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer

The mean platelet volume/platelet count ratio (MPV/PC) ratio based on the preoperative peripheral MPV and PCcan be used to predict the prognosis of multiple malignant tumors. MPV/PC may be used as a novel independent prognostic factor for patients with resectable cervical cancer. | Deng et al. BMC Cancer 2021 21 1282 https s12885-021-09016-8 RESEARCH Open Access Prognostic value of preoperative peripheral blood mean platelet volume platelet count ratio MPV PC in patients with resectable cervical cancer Qicheng Deng Qifang Long Yanan Liu Zhujuan Yang Yibei Du and Xin Chen Abstract Background The mean platelet volume platelet count ratio MPV PC ratio based on the preoperative peripheral MPV and PCcan be used to predict the prognosis of multiple malignant tumors. Objective To evaluate the prognostic value of MPV PC in cervical cancer patients. Methods This study enrolled 408 patients who had undergone radical surgery for cervical cancer and evaluated the correlation of MPV PC with patient prognosis in the primary cohort and validation cohort. Additionally independ- ent prognostic factors were incorporated to construct the prognostic nomogram and the area under the receiver operating characteristic ROC curve AUC value was calculated to analyze the prognostic predictive ability of the nomogram. Results In the primary cohort Kaplan Meier survival analysis indicated that the overall survival OS for patients with MPV PC was significantly lower than that in patients with MPV PC gt . MPV PC was an independent prog- nostic factor for resectable cervical cancer patients. Compared with neutrophil lymphocyte ratio NLR platelet lym- phocyte ratio PLR or monocyte lymphocyte ratio MLR the AUC values of MPV PC in predicting the 3- and 5-year survival rates for cervical cancer patients were greater. Similar results were verified in the validation cohort. Subse- quently the nomogram constructed based on MPV PC International Federation of Gynecology and Obstetrics FIGO classification and lymphovascular invasion performed well to accurately predict the prognosis of cervical cancer patients. The 3- and 5-year survival rates predicted by the nomogram were highly consistent with the real observa- tions. Similar results were also displayed in

• Y khoa - Dược
• BMC Cancer
• Cervical cancer
• Platelet count ratio
• Preoperative peripheral MPV
• Multiple malignant tumors
• Prognostic nomogram
• Cancer patient pathways
• Colorectal cancer
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• Oct4 overexpressing lung cancer
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