TAILIEUCHUNG - Optical properties of gold nano conjugated with proteins

The optical properties of protein-conjugated metallic nanoparticle are theoretically investigated based on the Mie theory and the core-shell model. Our numerical calculations show that this finding is in good agreement with previous experiments. We provide better interpretation for the origin of optical peaks in the absorption spectrum of the nanoparticle complex system. Our results can be used in biomedical applications. | OPTICAL PROPERTIES OF GOLD NANO CONJUGATED WITH PROTEINS Luong Thi Theu1 Le Anh Thi2 Tran Quang Huy1 Nguyen Quang Hoc3 Nguyen Minh Hoa4 1 Faculty of Physics Hanoi Pedagogical University 2 Vinh Phuc 2 Institute of Research and Development Duy Tan University Da Nang Vietnam 3 Faculty of Physics Hanoi National University of Education Hanoi Vietnam 4 Faculty of Basic Sciences Hue University of medicine and pharmacy Hue University Hue Vietnam Email nmhoa@huemed nguyenminhhoa@ Abstract The optical properties of protein conjugated metallic nanoparticle are theoretically investigated based on the Mie theory and the core shell model. Our numerical calculations show that this finding is in good agreement with previous experiments. We provide better interpretation for the origin of optical peaks in the absorption spectrum of the nanoparticle complex system. Our results can be used in biomedical applications. Keywords Gold nanoparticle BSA protein Mie theory. 1. Introduction Gold nanoparticles GNPs with a diameter between 1 nm and 100 nm have been widely used in chemical and biological sensors because of their excellent physical and chemical properties. The unique optical property of GNPs is one of the reasons that GNPs attract immense benefits from various fields of science especially in the development of sensors. The spherical GNP solutions show a range of vibrant colors including red blue and violet when the particle size increases and they can be used to dye glass in ancient times. The strong color is caused by the strong absorption and scattering of 520 nm light 1 which is the result of the collective oscillation of conduction electrons on the surface of GNPs when they are excited by the incident light. This phenomenon is called surface plasmon resonance SPR and it depends greatly on particle size and shape. Therefore the SPR peak can be adjusted by manipulating the size of GNPs and this property cannot be observed on bulk gold and GNPs with a .

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