TAILIEUCHUNG - Bioprospecting a native silver-resistant Bacillus safensis strain for green synthesis and subsequent antibacterial and anticancer activities of silver nanoparticles

Green nanomaterials have gained much attention due to their potential use as therapeutic agents. The present study investigated the production of silver nanoparticles (AgNPs) from a silver-resistant Bacillus safensis TEN12 strain, which was isolated from metal contaminated soil and taxonomically identified through 16S rRNA gene sequencing. The formation of AgNPs in bacterial culture was confirmed by using UV–vis spectroscopy with an absorption peak at nm. Fourier transform infrared (FTIR) spectroscopy confirmed the involvement of capping proteins and alcohols for stabilization of AgNPs. Moreover, X-ray diffraction analysis (XRD), scanning and transmission electron microscopy (SEM and TEM) confirmed the crystalline nature and spherical shape of AgNPs with particle size ranging from to nm. The energy dispersive X-ray spectroscopy (EDX) revealed that silver content is present in the nano-powder. AgNPs showed maximum antibacterial activity ( mm and mm inhibition zones) at 20 mg mL1 concentration against Staphylococcus aureus and Escherichia coli, respectively and significantly reduced the pathogen density in broth culture. Furthermore, AgNPs demonstrated significant anticancer effects in the human liver cancer cell line (HepG2) in MTT assay, whereas, no cytotoxic effects were demonstrated by AgNPs on normal cell line (HEK293). | Bioprospecting a native silver-resistant Bacillus safensis strain for green synthesis and subsequent antibacterial and anticancer activities of silver nanoparticles

• Sinh học
• Anticancer activity
• Antimicrobial activity
• Native silver resistant
• Subsequent antibacterial
• Silver nanoparticles
• Highly functionalized piperidines
• Piperidine derivatives
• Free radical scavenging
• DNA interaction
• Biological activity
• BMC Chemistry
• Hydrazonoyl chlorides
• Structure activity relationship
• Phenylhydrazinecarbo thioamide
• Thioxoquinazolin 4(3H) one
• Antioxidant activity
• Anticonvulsant activity
• Molecular docking
• Journal of Chemistry
• Piperazine chemistry
• Structural features
• Anticancer drugs
• D cyclin dependent kinase
• Benzimidazole derivatives
• Antiprotozoal activity
• Anti inflammatory activity
• Antimalarial activity
• Antimycobacterial activity
• Antiviral activity
• Biological synthesis
• Electron microscopy
• PC3 human prostate cancer cell lines
• QSSR models
• Physicochemical property
• Similar structures
• Flavones and isoflavones
• Fluorinated thiourea
• Antimicrobial and anticancer activity
• Biological activities
• Thiophene derivatives
• Anti microbial
• Substituted benzylideneamino
• ER alpha
• Valuable pharmacophore
• Molecular docking technique
• Reactive oxygen species
• Novel quinazolinone‑based rhodanines
• Pharmacological activities
• Benzoxazole molecules
• Synthesis and anticancer
• Substituted imidazolidinone sulfonamides
• National Cancer Institute
• Six synthesized sulfonamides
• BMC Cancer
• Heparanase inhibitors
• Triazolo thiadiazoles
• Attractive drug
• Genotoxic drug doxorubicin
• Mitochondriotoxic Hsp90
• Cancer therapy
• Vitamin D analogs
• Combined treatment
• 5 Fluorouracil
• Colon cancer
• MTT Assay
• Ribosome inactivating property
• Secondary structure
• Novel RIP from Trichosanthes dioica
• Isopropyl eugenoxyacetate
• Pt(II) complexes
• Pyridine derivatives
• Natural sciences
• Luận án Tiến sĩ
• Luận án Tiến sĩ Hóa học
• Organic chemistry
• Tubulysin derivatives
• Synthesis and evaluation
• Summary of Organic Chemistry doctoral thesis
• Organic Chemistry doctoral thesis
• Phosphorus oxychloride
• Nucleophilic substitution reactions
• Chloropyrimidine derivative
• Anticancer activities
• Thiourea derivatives
• Exhibited biological activities
• Benzenesulfonamide derivatives
• Metal complexes
• Cytotoxic activity
• Synthesized dicyanidoargentate
• DNA topoisomerase inhibition assays
• Chlorosulfonyl isocyanate (CSI)
• Benzoxathiazin 7 7 dioxide
• DPPH radical scavenging activity
• Synthesis and biological activity