TAILIEUCHUNG - Identification and anti-fungal resistance profile of different Candida species isolated from patients in ICUs

Candidiasis is one of the most predominant fungal infections that cause a major mortality of the patient. The epidemiology of candida infections have been witnessed a change round the world. We aimed to determine the distribution of candida species isolates from various clinical samples of patients in ICUs and evaluate its antifungal susceptibility to demonstrate the local resistance profile and guiding empirical treatment for clinicians. This study included 714 Candida isolates. Candida species were identified by MALDI-TOF mass spectrometry. Antifungal susceptibility tests were performed by Vitek 2 system. The percentage of NAC isolates () was higher compared with C. albicans (). The highest resistance rate in candida species was against amphotericin B (). However there was no resistance to caspofungin and micafungin reported. Regarding to voriconazole and fluconazoleanti fungal, the resistance rate of C. albicans were and respectively while of NAC species were , respectively. All C. krusei isolates were resistance to fluconazole. The study revealed increased the incidence of NAC over time. Although no remarkable resistance for antifungal agents in our hospital, we establish a critical need to antifungal stewardship program to prevent reaching the era of predominant Multi- drug resistance strain of Candida. | Identification and anti-fungal resistance profile of different Candida species isolated from patients in ICUs

• Sinh học
• Candida non albicans
• Antifungal susceptibility
• MSMALDI TOF
• Candida species isolated
• Patients in ICUs
• Anti fungal resistance profile
• Tạp chí y học
• Nghiên cứu y học
• Mức độ nhạy cảm
• Candida spp với fluconazole
• Định danh các chủng candida
• Candida albicans và candida non albicans
• Immuno compromised
• Candida albicans
• Candida non albicans
• Tertiary care hospital
• Candida species amongst various clinical samples
• Non – albicans Antifungal susceptibility
• Tertiary care teaching hospital
• Candida isolates from clinical samples
• Non albicans Candida
• Hospitalised patients
• CHROM agar
• Antifungal susceptibility testing
• Pathogen isolated
• Patients attending tertiary care centre
• Candiduria cases commonly observed
• Vulvovaginal Candidiasis
• Gynaecology department
• Women attending the obstetrics
• Prevalence of candida species
• Antifungal susceptibility isolated
• Blood culture at tertiary care hospital
• Blood culture
• Thuốc kháng nấm
• Nhiễm Candida máu trẻ
• Điều trị trẻ nhiễm Candida spp máu
• Nhóm C non albicans
• Nhiễm khuẩn huyết bệnh viện
• Diabetes mellitus
• Fluconazole resistance
• Tertiary care centre
• Gastrointestinal tract
• Histopathological examination
• Gastric perforation results arising
• Non steroidal anti inflammatory drugs
• History of use of NSAIDs
• BMC Anesthesiology
• Mechanical ventilation
• Intensive care
• Critically ill
• Non albicans species
• Candida bloodstream infections