TAILIEUCHUNG - Pertussis detection in children with cough of any duration

The diagnosis of pertussis in clinical practice continues to be a challenge worldwide as the symptoms are variable. We aimed to determine the prevalence of pertussis in Chinese children irrespective of cough duration and explore the clinical characteristics of children with pertussis with different cough durations. | Wu et al. BMC Pediatrics 2019 19 236 https s12887-019-1615-3 RESEARCH ARTICLE Open Access Pertussis detection in children with cough of any duration Check for updates r X s Ạ 1 s A 1 I 1 2 CA I 1 zx Z f h zx 2 IC 1 I I_Il I s zx2 I -X zx I I 2 A Ĩ I c h 12 I I rx ft _ A Ĩ f I IS ft4 A. I _ l ỉ I A I2 I_Il I M 2 -X zx zx Dan-Ăia wu Qiang Chen Kai-nu Yao Lan LI Wei Shi Jiang-Wei Ke Ai-Min wu Peng Huang ana Kun-Ling Shen1 Abstract Background The diagnosis of pertussis in clinical practice continues to be a challenge worldwide as the symptoms are variable. We aimed to determine the prevalence of pertussis in Chinese children irrespective of cough duration and explore the clinical characteristics of children with pertussis with different cough durations. Methods This was a prospective study of children 1 month to 11 years of age with different cough durations in one large Chinese hospital. Bilateral deep posterior nasopharyngeal swabs and venepuncture for full blood count CRP and serology and sputum were obtained when possible for investigation. E-test strips were used for testing the susceptibility of the isolates against erythromycin azithromycin sulphamethoxazole trimethoprim levofloxacin amoxicillin and doxycycline. Demographic clinical and laboratory information on culture and antimicrobial susceptibility testing was collected from children and analyzed using SAS SAS Institute Inc. USA . Results After exclusions we analyzed 312 children. Ninety-seven children had laboratory evidence of pertussis. When grouped by cough duration few characteristics were significant between children with and without pertussis. Of the 36 isolates 26 36 could not be inhibited by erythromycin and azithromycin at all. The MIC50 and MIC90 to amoxicillin were mg L and 1 mg L respectively sensitive to amoxicillin by the EUCAST points. Conclusions The one-size-fits-all clinical pertussis case definition is no longer optimal to recognize this .

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