TAILIEUCHUNG - Study of inducible Clindamycin resistance in Staphylococcus Aureus in a Tertiary care Hospital

Very few therapeutic options are available from the time of emergence of MRSA. Macrolide lincosamide streptogramin B (MSLB) antibiotics can be used in such scenarios with clindamycin being the preferred agent due to its excellent pharmacokinetic properties. Staphylococcal resistance to clindamycin may be inducible (iMLSB - inducible MacrolideLincosamide Streptogramin B resistance) or constitutive. The treatment of patients harbouring iMLSB Staphylococci with clindamycin leads to the development of constitutive resistance, subsequently leading to therapeutic failure. If inducible Clindamycin resistance can be reliably detected by placing relevant disc adjacent to each other at proper distance as a routine basis in clinically significant isolates, Clindamycin can be safely and effectively used in patients with true Clindamycin susceptible strains. Objective of the study is to determine prevalence of inducible clindamycin resistance in . 100 Staphylococcus aureus isolates collected from various clinical samples were subjected to routine antibiotic susceptibility testing and screening for Methicillin Resistance was done as per CLSI guidelines. Detection of inducible clindamycin resistance was done using Double disk diffusion test or D test. Out of 100 S. aureus (88 MRSA, 12 MSSA) isolates, prevalence of inducible clindamycin resistance was found to be 39% (39 isolates). Inducible Clindamycin resistance was found to be higher in MRSA (36 MRSA isolates) as compared to MSSA 25% (3 MSSA isolates). We conclude that whenever clindamycin is intended for S. aureus infection, the microbiology lab should tests the isolated organism for iMLSB by D test. | Study of inducible Clindamycin resistance in Staphylococcus Aureus in a Tertiary care Hospital

• Y khoa - Dược
• Methicillin resistant staphylococcus aureus
• Methicillin sensitive staphylococcus aureus
• Inducible clindamycin resistance
• Double disc diffusion method
• Tertiary care Hospital
• Staphylococcus aureus
• Prevalence of Staphylococcus aureus
• Staphylococcus aureus from milk
• Milk products
• Virulent gene characterization
• Bovine mastitis
• Staphylococcal enterotoxin genes
• Antimicrobial sensitivity pattern
• Methicillin resistant coagulase negative
• Staphylococcus isolated
• Various clinical samples
• Antimicrobial resistance
• Multidrug resistance
• Antibiogram of methicillin resistant Staphylococcus aureus
• Tertiary care rural hospital
• Investigate their sensitivity pattern
• Epsilometer test
• Retail meat shops and customers
• Neonatal septicemia
• Incidence of methicillin resistant
• Challenges in management
• Diabetic foot infections
• Diabetic foot Infection
• BMC Chemistry
• β Lactam affinity
• Healthcare associated MRSA
• Healthcare workers
• MRSA carriage
• Nasal carriage
• BMC Genomics
• Intercellular adhesion
• Biofilm production
• Antimicrobial therapy
• Coa gene
• Length polymorphism
• PCR restriction fragment
• Staphylococcus aureus based
• Molecular typing of methicillin resistant
• Methicillinresistant Staphylococcus aureus
• Polymerase chain reaction
• Bovine raw milk by PCR
• Antibacterial activities
• Plant extracts
• Methicillin resistant
• Non microbial origin
• Community acquired methicillin resistant
• Soft tissue infections
• Both health care
• Community settings now
• Poultry meat
• Antibiotic Sensitivity
• MecA gene
• Poultry house environment
• Detection and molecular characterization
• Methicillin resistant staphylococcus aureus obtained
• Burn patients
• Resistance pattern
• Changing trends in resistance pattern
• Health careassociated infections
• Antimicrobial susceptibility testing
• Health care worker
• Different areas of cardiac
• MSSA and chromogenic media
• ICU patients
• Oxacillin susceptible mecA positive isolates
• Bacteriological profile
• Chronic suppurative otitis media
• Aerobic bacteriological profile
• Special reference
• Susceptibility pattern
• Rural Kerala
• Tertiary care hospital study
• Prompt infection control measures
• World health organization
• MRSA infections
• Antibiotic susceptibility pattern
• Particular communities
• Antimicrobial susceptibility pattern
• Around Trivandrum
• Nasal swab and blood
• Antimicrobial chemotherapy
• Antibiotic sensitivity pattern
• Methicillin resistant staphylococcus aureus isolated
• Various clinical specimen
• Tertiary care post graduate teaching institute