TAILIEUCHUNG - P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review

Resistance of solid tumors to treatment is significantly attributed to pharmacokinetic reasons at both cellular and multi-cellular levels. Anticancer agent must be bio-available at the site of action in a cytotoxic concentration to exert its proposed activity. P-glycoprotein (P-gp) is a member of the ATP-dependent membrane transport proteins; it is known to pump substrates out of cells in ATP-dependent mechanism. The over-expression of P-gp in tumor cells reduces the intracellular drug concentrations, which decreases the cytotoxicity of a broad spectrum of antitumor drugs. Accordingly, P-gp inhibitors/blockers are potential enhancer for the cellular bioavailability of several clinically important anticancer drugs such as, anthracyclines, taxanes, vinca alkaloids, and podophyllotoxins. Besides several chemically synthesized P-gp inhibitors/ blockers, some naturally occurring compounds and plant extracts were reported for their modulation of multidrug resistance; however, this review will focus only on major classes of naturally occurring inhibitors viz., flavonoids, coumarins, terpenoids, alkaloids and saponins. | P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review

• Hoá học
• Multidrug resistance
• Multidrug resistance associated protein 1
• Natural products
• P glycoprotein
• Hospital acquired infections
• Extended spectrum beta lactamases
• Beta lactamase prevalence
• Multidrug resistance burden
• Incidence rate
• Antimicrobial resistance
• Central venous catheter blood stream infections
• Multidrug resistance pattern in confirmed cases
• Multidrug resistance pattern
• Penicillin resistance
• Streptococcus pneumoniae
• Tertiary care hospital
• Study of penicillin resistance
• Pre extensively drug resistance
• Extensively drug resistance
• Pulmonary multidrug resistant tuberculosis
• Patient by line probe assay
• Reliable methods
• Microbial Drug Resistance
• Ecology of Antibiotic Resistance Genes
• Multidrug Efflux Pumps
• Bacterial Resistance to Antimicrobials
• Global Response Systems That Confer Resistance
• Mechanisms of Aminoglycoside Antibiotic Resistance
• Efflux activity
• Efflux pumps
• Antibiotic withdrawal
• Multidrug resistant Escherichia coli
• BMC Cancer
• UDP glucose ceramide glycosyltransferase
• Sphingolipid metabolism
• GSL metabolic pathway
• Luận án Tiến sĩ
• Summary of Biology doctoral thesis
• Biology doctoral thesis
• Multidrug resistant Salmonella
• Related genes
• Resistance characteristics
• Methicillin resistant staphylococcus aureus
• Tertiary care rural hospital
• Investigate their sensitivity pattern
• Summary of Doctoral Thesis in Biology
• Doctoral Thesis in Biology
• Preventive bundle
• Catheter associated urinary tract infection
• BMC Pharmacology and Toxicology
• p toluenesulfonyl hydrazinothiazoles
• Bacterial multidrug resistance
• Wnt/β catenin signaling
• Molecular docking
• Burn patients
• Resistance pattern
• Changing trends in resistance pattern
• Multidrug resistant E coli isolated
• Showing high resistance
• Multi drug resistance
• Antibacterial agents
• Vitro sensitivity towards
• ZnO phytonanocomposite
• Strychnos nux vomica
• Antibacterial activity
• Strychnos nux vomica L
• Drinking water
• Antibiotic resistance
• Multidrug resistant salmonella spp
• Potable water collected
• Slum areas of Bhopal
• Optical density
• Cartwheel method
• Efflux pump activity
• Multidrug resistant
• E coli isolates
• Extracellular vesicles
• Immune evasion
• Cell engulfment
• Door handles
• Microbial contamination
• Multidrug resistant staphylococcus aureus
• Door handles as potential reservoirs
• BMC Pulmonary Medicine
• Mechanical ventilator weaning
• Bacterial pneumonia
• Antimicrobial therapy
• Crosssectional study
• Various clinical samples
• Tertiary care centre Jhalawar
• Biofilm producing uropathogens
• Drug resistance
• Dual foe for patients
• Patients on urinary catheter
• Outer membrane proteins
• Multidrugresistant Klebsiella isolates
• Minimal inhibitory concentrations
• Mechanism of resistance
• Resistance patterns of the tested isolates