TAILIEUCHUNG - Primary enteric-type adenocarcinomas of the urinary bladder are histogenetically analogous to colorectal carcinomas: Immunohistochemical evaluation of 109 cases

Primary enteric-type adenocarcinoma of the urinary bladder is relatively uncommon. We present our experience with 109 pure, non-urachal cases—the largest series to date. This work was undertaken with the aim of describing the immunohistochemical features of adenocarcinoma of the urinary bladder associated with schistosomiasis, illustrating their histologic and immunohistochemical similarities to colorectal carcinomas. Partial or total cystectomy specimens from a cohort of Egyptian and American patients with the diagnosis of primary adenocarcinoma of the urinary bladder (109 cases) were reviewed. Paraffin sections of each tumour were stained using the labelled streptavidin–biotin method using antibodies cytokeratin 20, cytokeratin 7, CDX2, MLH1, and villin. Clinical follow-up was available for at least 36 months. An enteric (colonic) morphology was seen in most tumours; some with signet ring cells or mucinous elements. Five tumours were composed predominantly of signet ring cells and two demonstrated a pure mucinous morphology. In cases where adjacent normal mucosa was present, 23% showed either colonic metaplasia or intestinal-type cystitis glandularis. Furthermore, 24% of enteric-type adenocarcinomas had associated villous or tubulovillous adenomas with or without dysplasia. Cytokeratin 20 was expressed by 90%, cytokeratin 7 by 17%, CDX2 by 100% and villin and MLH1 by 76% and 48% of tumours respectively. The majority of tumours presented with an advanced stage and followed an aggressive clinical course. | Primary enteric-type adenocarcinomas of the urinary bladder are histogenetically analogous to colorectal carcinomas: Immunohistochemical evaluation of 109 cases

• Y khoa - Dược
• Urinary bladder
• Primary enteric type adenocarcinomas
• Histogenetically analogous
• Colorectal carcinomas
• Immunohistochemical evaluation
• Bladder Cancer
• Urine markers
• Non muscle invasive bladder cancer
• Nuclear matrix protein 22
• Urinary bladder cancer antigen
• Urinary bladder carcinoma
• Muscularis propris invasion
• Urinary bladder carcinoma cases
• Muscularis propria invasion
• Detection of Muscularis propria invasion
• BMC Cancer
• Upper urinary tract urothelial cancer
• Double J stent
• Transurethral resection of bladder tumour
• Urothelial carcinoma of the urinary bladder
• Relative survival
• Registry data
• Urinary bladder neoplasms
• Intravesical administration
• 2 methacryloyloxyethyl phosphorylcholine
• Clinical trial
• Next generation sequencing
• Urinary assay
• Urinary biomarker
• Upper tract urothelial carcinoma
• Radical cystectomy
• Radical nephroureterectomy
• Upper urinary tract
• Urinary exosomes
• Quality of life
• Promising biomarker
• B cell translocation gene
• Advanced urodynamics
• Neurogenic bladder obstruction
• Iatrogenic female bladder Outlet obstruction
• Pelvic organ prolapse
• Augmented lower urinary tract
• Lower urinary tract anomalies
• Urine based assay
• DNA biomarkers
• Carcinoma in situ
• Muscle invasive bladder cancer
• Lymph nodes
• Age at diagnosis
• Muscle invasive bladder urothelial carcinoma
• Multivariate analyses
• Urinary bladder neoplasm
• Plasmacytoid variant
• Adjuvant cisplatin based chemotherapy
• Cox’s proportional hazards
• Intravesical therapy
• Propensity score matching
• Landmark analysis
• Genome Biology
• Urinary bladder cancers
• Subtype associated epigenomic landscape
• 3D genome structure
• Urinary metabolomics
• Potential biomarker
• Cancer diagnosis
• báo cáo khoa học
• báo cáo hóa học
• công trình nghiên cứu về hóa học
• tài liệu về hóa học
• cách trình bày báo cáo
• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• ABC of urology
• Urological evaluation
• Bladder outflow obstruction
• Urinary incontinence
• Urological emergencies
• Prostate cancer
• Smith’s general urology
• Urologic tumors
• Renal parenchymal neoplasms
• Neuropathic bladder disorders
• Bladder substitution
• Urinary diversion
• Squamous cell carcinoma of the bladder
• Survival analysis
• Significant clinical parameters
• Establish nomograms
• Urinary tract
• Detect disease recurrence
• Oral metformin
• Basal cell
• Molecular subtype
• Neoplasm metastasis
• Squamous cell
• Small cell carcinoma of the bladder
• Contrast enhanced ultrasound
• Conventional ultrasound
• Time intensity curves
• Antidepressive agents
• Delayed diagnosis
• Treatment outcome