TAILIEUCHUNG - Nanosuspensions containing Oridonin/HP-β-cyclodextrin inclusion complexes for oral bioavailability enhancement via improved dissolution and permeability

Chemotherapy via oral route of anticancer drugs offers much convenience and compliance to patients. However, oral chemotherapy has been challenged by limited absorption due to poor drug solubility and intestinal efflux. In this study, we aimed to develop a nanosuspension formulation of oridonin (Odn) using its cyclodextrin inclusion complexes to enhance oral bioavailability. Nanosuspensions containing Odn/2 hydroxypropyl-β-cyclodextrin inclusion complexes (Odn-CICs) were prepared by a solvent evaporation followed by wet media milling technique. The nanosuspensions were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and dissolution. The resulting nanosuspensions were approximately nm in particle size and presented a microcrystal morphology. Nanosuspensions loading OdnCICs dramatically enhanced the dissolution of Odn. Further, the intestinal effective permeability of Odn was markedly enhanced in the presence of 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and poloxamer. Bioavailability studies showed that nanosuspensions with Odn-CICs can significantly promote the oral absorption of Odn with a relative bioavailability of (Odn suspensions as reference). | Nội dung Text Nanosuspensions containing Oridonin HP-β-cyclodextrin inclusion complexes for oral bioavailability enhancement via improved dissolution and permeability

• Y khoa - Dược
• Cyclodextrin inclusion complexes
• Oral bioavailability enhancement via
• Improved dissolution
• Intestinal efflux
• Compliance to patients
• Journal of Chemistry
• β cyclodextrin
• Inclusion complexes
• Anionic surfactants
• Organic reactions
• Green procedure
• BMC Musculoskeletal Disorders
• Patient compliance
• Real time monitoring
• Brace treatment
• Adolescent idiopathic scoliosis
• Arterial stiffness
• Chronic kidney disease
• Compliance index
• Glomerular filtration rate
• Major adverse event
• Non compliance
• Risk factors
• Dots plus centres
• Assessment of risk factors
• MDR TB patients
• Reasons behind their admission
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• BMC Pediatrics
• Psychopatologic traits
• Adult chronic periodontitis
• Vice versa
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• Nuclear family
• Poor compliance
• Highly active antiretroviral therapy
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• Human immunodeficiency virus
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• Colorectal cancer
• Early detection
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• Enhanced recovery after surgery
• Postoperative complications
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• Continuous positive airway pressure therapy
• Side effects
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