TAILIEUCHUNG - Improved skin penetration using in situ nanoparticulate diclofenac diethylamine in hydrogel systems: In vitro and in vivo studies

Delivering diclofenac diethylamine transdermally by means of a hydrogel is an approach to reduce or avoid systemic toxicity of the drug while providing local action for a prolonged period. In the present investigation, a process was developed to produce nanosize particles (about 10 nm) of diclofenac diethylamine in situ during the development of hydrogel, using simple mixing technique. Hydrogel was developed with polyvinyl alcohol (PVA) ( w/w) and carbopol 71G ( w/w). The formulations were evaluated on the basis of field emission scanning electron microscopy, texture analysis, and the assessment of various physiochemical properties. Viscosity (163–165 cps for hydrogel containing microsize drug particles and 171–173 cps for hydrogel containing nanosize drug particles, respectively) and swelling index (varied between and ) data favor the hydrogels for satisfactory topical applications. The measured hardness of the different hydrogels was uniform indicating a uniform spreadability. | Nội dung Text Improved skin penetration using in situ nanoparticulate diclofenac diethylamine in hydrogel systems In vitro and in vivo studies

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• Anti inflammatory
• Cadaver skin
• Nanosize dispersion
• Permeation enhancement
• In vivo studies
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