TAILIEUCHUNG - Effect of adrenomedullin gene delivery on insulin resistance in type 2 diabetic rats

Type 2 diabetes mellitus is one of the common metabolic disorders that ultimately afflicts large number of individuals. Adrenomedullin (AM) is a potent vasodilator peptide; previous studies reported development of insulin resistance in aged AM deficient mice. In this study, we employed a gene delivery approach to explore its potential role in insulin resistance. Four groups were included: control, diabetic, non-diabetic injected with the AM gene and diabetic injected with the AM gene. One week following gene delivery, serum glucose, insulin, triglycerides, leptin, adiponectin and corticosterone were measured as well as the insulin resistance index (HOMA-IR). Soleus muscle glucose uptake and RT-PCR of both AM and glucose transporter-4 (GLUT 4) gene expressions were assessed. A single tail vein injection of adrenomedullin gene in type 2 diabetic rats improved skeletal muscle insulin responsiveness with significant improvement of soleus muscle glucose uptake, HOMA-IR, serum glucose, insulin and triglycerides and significant increase in muscle GLUT 4 gene expression (P | Effect of adrenomedullin gene delivery on insulin resistance in type 2 diabetic rats

• Y khoa - Dược
• Insulin resistance
• Muscle glucose uptake
• Adrenomedullin gene delivery
• Insulin resistance
• Type 2 diabetic rats
• BMC Pediatrics
• Obesity related insulin resistance
• Chronically elevated insulin concentrations
• Homeostatic model
• Aerobic exercise
• Resistance exercise
• Inflammatory cytokine
• Obese type 2 diabetic patients
• Plasma 25 hydroxyvitamin D
• Insulin Vitamin D
• Pathological factors
• Gestational diabetes mellitus
• BMC Veterinary Research
• Equine metabolic syndrome
• Beta‐cell response
• Insulin dysregulation
• Type 2 diabetes
• Beta cell function
• Oral hypoglycemic agent
• Dipeptidyl peptidase 4 inhibitors
• Hypoglycemic agent
• Non alcoholic fatty liver disease
• Phosphodiesterase 3B
• Oxidative stress
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• Pro inflammatory cytokines
• Portal hemodynamics
• Glucose metabolism
• Portal haemodynamic abnormality
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• Summary of doctoral dissertation
• Researching clinical features
• Target organ lesions and target insulin resistance
• New hypertensive patients with impaired fasting glucose
• New hypertensive patients
• Impaired fasting glucose
• Child obesity
• Metabolic syndrome
• Homeostasis Model Assessment Insulin Resistance
• High Density Lipoprotein Cholesterol
• Abdominal obesity
• Physical activity
• Childhood obesity
• Anthropometric measurements
• Neck circumference
• Cardiometabolic risk
• BMC Cancer
• Endometrial cancer
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• Diabetes mellitus
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• Visceral Fat
• Insulin
• Resistance
• Sarika Arora
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• Birth weight
• Developing diabetes
• Homeostasis Model assessment for Insulin Resistance
• Small for gestational age
• Insulin sensitivity
• Fat mass
• Childhood obesity epidemic
• Whole body vibration
• Glucose dynamics
• Cardiometabolic disease
• β cell function
• Body mass index