TAILIEUCHUNG - In vitro assessment of pharmaceutical potential of ethosomes entrapped with terbinafine hydrochloride

The present study investigates the entrapment of terbinafine hydrochloride (TH) in ethosomal vesicles via unsonicated and sonication method. Carbopol 934P was incorporated in the best formulation, F6, obtained by sonication method. The formulated ethosomal gel obtained as such . F6* was exploited to achieve a zero order release profile of TH. The composition includes phospholipid, ethanol and propylene glycol. Drug entrapment efficiency (DEE), invitro and ex-vivo drug diffusion studies, FT-IR and stability studies of the prepared ethosomes were investigated. The size and shape of F6 ethosomes vesicles were characterized by SEM. Invitro drug release studies were performed using sigma dialysis membrane in phosphate buffer, pH for 12 h while drug content was determined by HPLC. DEE was ranked from ± to ± . Highest DEE was seen with F6 ethosomal formulation with a vesicle size of 248 ± nm. FT-IR studies confirmed that there was no chemical interaction between drug and excipients used in the formulation. Ex-vivo result suggested that drug diffusion observed after 12 h from F6* and marketed cream (MR) formulations was ± and ± , respectively. The results of similarity factor (f2 values) for MR and F6* ethosomal gel were and , respectively. It revealed that F6* showed dissimilar dissolution profiles. Transdermal flux value for F6* and MR was found to be ± lg/cm2 /h and ± lg/cm2 /h, respectively. This study disclosed that F6* resides at targeted site for a relatively longer period of time thereby signifying the improved patient compliance. | In vitro assessment of pharmaceutical potential of ethosomes entrapped with terbinafine hydrochloride

• Y khoa - Dược
• In vitro drug diffusion
• Terbinafine Hydrochloride
• Transdermal flux
• Ethosomes entrapped
• Vitro assessment
• Goat milk
• In vitro assessment
• Antibiotic resistance pattern
• Lactobacillus strains isolated
• In vitro
• Nodal explants
• ISSR markers
• Assessment of genetic fidelity
• Acclimatized plantlets
• Simplified in Vitro propagation protocol
• Combining phases of in Vitro
• Propagation and rooting
• Genetic uniformity of regenerated plantlets
• Highly effective production
• Naja siamensis antivenom
• NS antivenom purification
• NS antivenom in current treatment
• Quality control of NS antivenom
• In vitro and in vivos animal model
• Potency test of NS antivenom
• SSR markers
• Dianthus giganteus subsp
• banaticus
• Ex situ conservation
• In vitro culture
• Somaclonal variability
• Genetic fidelity
• Encapsulated in vitro tissues
• Bacopa monnieri L
• Inter simple sequence repeat
• Random amplified polymorphic DNA
• BMC Chemistry
• E cigarette aerosol
• Cigarette smoke
• In vitro exposure systems
• Borgwaldt RM20S
• Vitrocell VC10
• Gladiolus hybrida
• Growth regulators
• In vitro regeneration
• RAPD markers
• gladiolus (Gladiolus hybrida L )
• Pulsatile release
• Sustained release
• Bilayer tablet
• Chronological release profile
• Etodolac from coated bilayer tablets
• In vivo assessment
• Trichoderma sps
• Antagonistic activity
• Trichoderma species
• Different fungicides in vitro
• Significant reduction in radial growth
• The antioxidant power
• In vitro obtained coleus forskohlii briq
• Non enzyme antioxidant
• Secondary metabolites synthesis
• Coleus forskohlii Briq
• Plant growth regulators
• In vitro micropropagation
• Metabolic profiles of melissa officinalis l
• GC/MS analysis
• Medicinal plant
• Toxicological Methods
• Inhalation Toxicology
• Efficacy Testing
• Assessment Alternatives
• effective alternatives
• Vitro Toxicology
• báo cáo khoa học
• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
• Viola patrinii
• Leaf explants
• Micropropagated plants
• Random amplified polymorphic DNA
• BMC Pharmacology and Toxicology
• In vitro cytotoxicity
• Neuronal cell cultures
• Retinoic acid treated P19 cells
• Nerve growth factor treated PC12 cells
• Okadaic acid
• Anti cancer activity
• MTT assay
• LDH assay
• Micro organisms
• Cancer cell lines
• The antiviral activity of greek bee bread
• Bee collected pollen against enterovirus D68
• Real Time PCR assay
• Antiviral activity against EV D68
• Bee hive products