TAILIEUCHUNG - Ribosomal protein L15 is involved in colon carcinogenesis

Ribosomal biogenesis is responsible for protein synthesis in all eukaryotic cells. Perturbation of ribosomal biogenesis processes can cause dysfunctions of protein synthesis and varieties of human diseases. In this study, we examine the role of RPL15, a large ribosomal subunit protein, in human colon carcinogenesis. | Int. J. Med. Sci. 2019 Vol. 16 1132 IVYSPRING ĩvt ơ-rnrt irmrtí clrni t n lí ei-fCMo Tir lT Qriữvtrơc INTERNATIONAL PUBLISHER international journal Oj jVLeaicaiSciences 2019 16 8 1132-1141. doi Research Paper Ribosomal Protein L15 is involved in Colon Carcinogenesis Zhixiong Dong1-2-3 Hongyu Jiang2 3 Shuangshuang Liang2 5 Yajie Wang2 3 Wei Jiang3 4 J Changun Zhu2 3 1. Key Laboratory of Laboratory Medicine School of Laboratory Medicine and Life Science Wenzhou Medical University Wenzhou Zhejiang 325035 China 2. Tianjin Key Laboratory of Animal and Plant Resistance College of Life Sciences Tianjin Normal University Tianjin 300387 China 3. Key Laboratory of Molecular and Cellular Systems Biology College of Life Sciences Tianjin Normal University Tianjin 300387 China 4. State Key Laboratory of Molecular Oncology Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China 5. AstraZeneca Pharmaceutical Co Ltd Xi an 710100 China. Corresponding author Changjun Zhu Email skyzcj@ We Jiang Email jiang6138@ Zhixiong Dong Email dongzx882@. The author s . This is an open access article distributed under the terms of the Creative Commons Attribution License https licenses by . See http terms for full terms and conditions. Received Accepted Published Abstract Ribosomal biogenesis is responsible for protein synthesis in all eukaryotic cells. Perturbation of ribosomal biogenesis processes can cause dysfunctions of protein synthesis and varieties of human diseases. In this study we examine the role of RPL15 a large ribosomal subunit protein in human colon carcinogenesis. Our results reveal that RPL15 is remarkably upregulated in human primary colon cancer tissues and cultured cell lines when compared with paired non-cancerous tissues and non-transformed epithelium cells. Elevated expression of RPL15 in .

• Y khoa - Dược
• Ribosome biogenesis
• Colon cancer
• Apoptosis 15
• Human colon carcinogenesis
• Protein synthesis
• BMC Cancer
• Breast cancer
• Distinctive trait
• Cancer cells
• BMC Bioinformatics
• Stress response
• Co expression
• Co regulation
• Genome wide analysis
• Budding yeast
• Cell migration
• Eukaryotic Initiation factor 6
• Peculiar translation initiation factor
• Genome Biology
• Genetic variation
• Translational efficiency
• Ribosome profiling
• Cardiac hypertrophy
• Complex disease
• Ribosomal DNA
• Human diploid genome
• Physiological conditions
• Diamond Blackfan anemia
• Protein production
• Human congenital diseases
• Xenopus tropicalis
• BMC Molecular and Cell Biology
• 25S ribosomal RNA molecules
• Candida albicans
• Initial analysis pointed
• RNA cap specific antibody
• During tumorigenesis
• Cancer cells increase
• Multi domain enriched
• Stem cells
• BMC Genomics
• Bone marrow mesenchymal stem cells
• Osteogenic differentiation
• Adipogenic differentiation
• Cell surface photoreceptors
• Integrated analysis
• Human cancers
• Clinical prognosis