TAILIEUCHUNG - Study the application of public cord blood stem cell transplantation for Leukemia treatment (from 10-2016 to 9-2018)

To describe the quality of cord blood stem cell stored in Stem Cell Bank of National Institute of Hematology and Blood Transfusion, to assess the initial results of cord blood transplantation for acute leukemia treatment. | Journal of military pharmaco-medicine no1-2019 STUDY THE APPLICATION OF PUBLIC CORD BLOOD STEM CELL TRANSPLANTATION FOR LEUKEMIA TREATMENT (FROM 10 - 2016 TO 9 - 2018) Bach Quoc Khanh1; Tran Ngoc Que1; Nguyen Ba Khanh1,2; Vo Thi Thanh Binh1 Dang Thi Thu Hang2; Nguyen Vu Bao Anh1,2; Nguyen Tuan Tung3 Kieu Thi Van Oanh3; Vu Duy Hong1; Duong Quoc Chinh1 Hoang Thi Thanh Nga1; Nguyen Anh Tri1 SUMMARY Objectives: To describe the quality of cord blood stem cell stored in Stem Cell Bank of National Institute of Hematology and Blood Transfusion, to assess the initial results of cord blood transplantation for acute leukemia treatment. Subjects and method: Interventional, retrospective and prospective study. Subjects included 3,466 public cord blood units which were successfully stored, 05 patients with acute leukemia, transplanted by cord blood stem cell, in National Institute of Hematology and Blood Transfusion, from October of 2016 to September of 2018. Results: After 02 years of following up, among 3,466 stored public cord blood units, the 7 5 mean total nucleated cell was ± x 10 , the mean CD34 cell was ± x 10 , the post-thawed viability of stem cells was ± ; there were 30 acute leukemia patients who were indicated for stem cell searching in public cord blood bank and the rate of successful search was ; 05 patients were transplanted using the matched stem cell units; among that, 02 patients achieved stable engraftment; the most common complications were mucosal ulceration (100%), bacteremia (100%) and CMV reactivation (100%); graft versus host disease happened in 01 case; 03 mortality cases were all due to severe sepsis. Conclusion: Allogeneic cord blood transplantation is a promising and effective method for the treatment of acute leukemia. * Keywords: Acute leukemia; Allogeneic; Stem cell transplantation; Cord blood; Stem cell. INTRODUCTION Acute leukemia is one of the most malignant hematological diseases with very high mortality .

• Y khoa - Dược
• Acute leukemia
• Acute leukemia treatment
• Stem cell transplantation
• Cord blood
• Stem cell
• Haemopoietic stem cell transplant
• BMC Cancer
• Acute promyelocytic leukemia
• Acute myeloid leukemia
• Describe factors
• Anti bacterial prophylaxis
• Childhood acute leukemia
• Accurate cloning
• Standardize morphology
• Chronic myeloid leukemia
• Imatinib mesylate
• Leukemia markers
• Anti leukemia drugs in myeloid leukemia
• Acute lymphoblastic leukemia
• Chronic lymphocytic leukemia
• Analytical validation
• Multiple myeloma
• Measurable residual disease
• Minimal residual disease
• Case rep
• Chemotherapeutic agents
• Prognostic significant
• YP3A4 A 290G polymorphism
• Healthy control using PCR
• Acute myeloid leukemia patients
• Relapse analysis
• Childhood acute lymphoblastic leukemia
• Hue Central Hospital
• Pediatrics oncology
• BMC Pediatrics
• Final height
• Body mass index
• Childhood acute lymphoblastic leukemia treated
• Relapse childhood
• Developing countries
• Childhood acute myeloid leukemia
• Allogeneic hematopoietic stem cell transplantation
• Pediatric acute myeloid leukemia
• Overall survival
• Extramedullary relapse
• Case report
• Acute T lymphoblastic leukemia
• Hematopoietic stem cell transplantation
• Therapy outcomes
• B cell acute lymphoblastic leukemia
• Multiplex RQ PCR
• Bone Sialoprotein 1
• CD44 variant 6
• Receptor CD44 Variant 6
• Role of bone sialoprotein 1
• Non Hodgkin’s lymphoma
• Related acute myeloid leukemia
• Hodgkin’s lymphoma
• Related acute myeloid leukemia following chemotherapy
• Journal of clinical Medicine
• A20 on glucose dependent cell migration in acute lymphoblastic leukemia
• Peripheral blood mononuclear cells
• Determined by quantitative RT PCR
• Gene expression profile
• Retinoic acid receptor alpha
• Alltrans retinoic acid
• Bone marrow smear
• Deep learning
• Artificial intelligence
• Lymphoblastic Leukemia
• Clustering Analysis
• Epidemiological Evidence
• Phase I
• Myelodysplastic syndrome
• Chronic myelomonocytic leukemia
• Classification
• Under Resourced Laboratories
• Molecular Mechanisms
• Markers
• Tyrosine kinase inhibitor
• Kinase inhibitors
• Donor leukemia
• Whole exome sequencing
• Familial acute lymphoblastic leukemia
• Childhood leukemia predisposition
• Fanconi anemia genes
• Hematopoietic dysfunction