TAILIEUCHUNG - Mutation analysis of EGFR and FGFR gene in glioblastoma patients in Vietnam

Glioblastoma is the most prevalence primary malignant brain tumor, which takes up 16% of all primary brain and central nervous system malignancy. Molecular variations or gene expression patterns have also been recognized in primary and secondary glioblastomas. Genetic typical alterations for primary glioblastoma are epidermal growth factor receptor and fibroblast growth factor receptors variations. | Journal of military pharmaco-medicine no1-2019 MUTATION ANALYSIS OF EGFR AND FGFR GENE IN GLIOBLASTOMA PATIENTS IN VIETNAM Kieu Dinh Hung1; Nguyen Thi Thom1; Tran Quoc Dat1; Dang Thi Ngoc Dung1 Tran Huy Thinh1; Tran Van Khanh1; Ta Thanh Van1 SUMMARY Background: Glioblastoma is the most prevalence primary malignant brain tumor, which takes up 16% of all primary brain and central nervous system malignancy. Molecular variations or gene expression patterns have also been recognized in primary and secondary glioblastomas. Genetic typical alterations for primary glioblastoma are epidermal growth factor receptor and fibroblast growth factor receptors variations. Subjects and methods: We recruited 60 patients diagnosed with primary glioblastoma in which biopsy samples were collected to assess for FGFR and EGFR mutations. Results and conclusion: 6/60 patients () were positive with FGFR mutation (, , ). 8/60 patients () were identified with EGFR, a total of 7 mutations were identified , , , , , , . This is the first study on FGFR and EGFR mutation in glioblastoma patients in Vietnam. The results would contribute to better understanding the pathological and molecular mechanism of glioblastoma in Vietnam. * Keywords: Glioblastoma; EGFR; FGFR; Mutation analysis. INTRODUCTION Glioblastoma (GBM) is the most prevalence primary malignant brain tumor, which take up 16% of all primary brain and central nervous system malignancy [1]. The average age-adjusted incidence rate in the population is per 100,000 [1]. GBMs were primary thought to be resulting exclusively from glial cells; however, recent studies suggest that they may result from several cell types with neural stem cell-like properties [2]. By the end of the genomic profiling and the Cancer Genome Atlas project (Parsons et al 2008), more than 600 genes were profiled from more than 200 human tumor samples, which revealed the complex genetic .

• Y khoa - Dược
• Mutation analysis
• Glioblastoma patients in Vietnam
• Secondary glioblastomas
• Genetic typical alterations
• Primary glioblastoma
• Fibroblast growth factor
• BMC Bioinformatics
• Somatic mutation burden
• Mutation rate heterogeneity
• Mutation rate estimation
• Mutation count overdispersion
• BMC Genomics
• Adaptive laboratory evolution
• Mutation functional analysis
• Mutation meta analysis
• Mutation convergence
• Multiscale genome annotation
• Genome Biology
• Cancer gene prediction
• Cancer somatic mutation
• Cancer genomes
• Mutation frequency
• Functional gene network
• Pathway centric analysis
• BMC Cancer
• Germline TET2 mutation
• Somatic TET2 mutation
• Myelodysplastic syndromes
• Acute myeloid leukemia
• Circulating tumor cells
• Single cell analysis
• Tumor genotypes
• Cancer cell culture
• Disseminated tumor cells
• Metastatic colorectal carcinoma
• Formalin fixed
• Paraffin embedded
• Overall survival
• Meta analysis
• Prognostic implication
• TERT promoter mutation
• NPM1 mutation
• Hierarchical cluster analysis
• Tumor mutation burden
• Lung cancer
• Non small cell lung cancer
• Uterine leiomyoma
• Somatic mutation
• Multiple leiomyoma
• Gynecologic tumors
• MED12 mutation
• báo cáo khoa học
• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
• Biological information
• Lecture Genetics
• Human genetics
• Dissection through mutation
• Genetic analysis
• Gene structure
• SLC25A13 gene
• Splicing mutation
• Amplicon sequencing
• Pedigree analysis
• Jaundice related genes
• BMC Pediatrics
• Schimke immune osseous dysplasia
• Next generation sequencing
• Special facial features
• Brain metastasis
• Epidermal growth factor receptor mutation
• Tyrosine kinase inhibitor
• Oncocytic carcinoma
• Nuclear mitochondrial complex I subunits
• Oncogene mutation analysis
• Mitochondrial abundance
• Gefitinib maintenance treatment
• EGFR mutation
• Cost effectiveness
• Survival analysis
• Cancer treatment
• Essential factors
• Immunotherapeutic efficacies
• Immune infiltration
• Differential evolution
• Direct design
• Nonlinear inelastic analysis
• Self adaptive mutation differential evolution
• Members of truss structures
• Mutational signatures
• Cancer genomics
• Single nucleotide variants
• Mutation Annotation Format
• Pancreatic cancer
• Pancreatic juice
• Liquid biopsy
• Sanger sequencing
• High resolution melting analysis
• Analytical validation
• Limit of detection
• Somatic mutation
• Hybridization Analysis
• Chromosomal Deletions
• Microsatellite Analysis
• DNA Fingerprinting
• Human Cancer