TAILIEUCHUNG - Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats
In the present study, we tried to investigate the effects of melatonin, a novel antioxidant and a potent free radical scavenger, in stress-induced cerebral, cerebellar, cardiac, and hepatic oxidative damage using microscopic and biochemical analysis. A total of 32 male Wistar albino rats were divided into control, stress, stress + saline, and stress + melatonin groups. | Turkish Journal of Biology Turk J Biol (2014) 38: 493-501 © TÜBİTAK doi: Research Article Melatonin is effective in reducing stress-induced organ damage in Wistar albino rats 1, 2 3 3 3 4 Mukaddes EŞREFOĞLU *, Ayşin AKINCI , Hülya ELBE , Elif TAŞLIDERE , Aslı ÇETİN , Burhan ATEŞ Department of Histology and Embryology, Faculty of Medicine, Bezmialem Vakıf University, İstanbul, Turkey 2 Doğu Fertil Tüp Bebek Merkezi, Malatya, Turkey 3 Department of Histology and Embryology, Faculty of Medicine, İnönü University, Malatya, Turkey 4 Department of Biochemistry, Faculty of Science and Art, İnönü University, Malatya, Turkey 1 Received: Accepted: Published Online: Printed: Abstract: In the present study, we tried to investigate the effects of melatonin, a novel antioxidant and a potent free radical scavenger, in stress-induced cerebral, cerebellar, cardiac, and hepatic oxidative damage using microscopic and biochemical analysis. A total of 32 male Wistar albino rats were divided into control, stress, stress + saline, and stress + melatonin groups. The rats from the stress groups were exposed to high stress conditions of starvation, immobilization, and cold exposure. The rats from the stress + melatonin group received melatonin daily at 20 mg/kg body weight intraperitoneally for 7 days. At the end of the experiment, the brain, cerebellum, heart, and liver were rapidly removed. The main histopathological damage scores (MHDSs) of the stress and stress + saline groups were higher than those of control group for all of the organs. The MHDSs of melatonin-administered group were lower than those of stress and stress + saline groups. The main tissue superoxide dismutase activities of the stress + melatonin group were even higher than those of the control group in the cerebellum and liver, and main tissue catalase activities of the stress + melatonin group were even
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