TAILIEUCHUNG - The effect of survivin gene promoter polymorphism on breast cancer
Breast cancer is the most common malignant tumor in women and accounts for about 25% of all cancer diagnoses. Survivin is a member of the apoptosis inhibitor protein family of antiapoptotic proteins. In our study, we investigated one of those, the survivin gene promoter 31G/C polymorphism. | Turkish Journal of Biology Turk J Biol (2014) 38: 858-866 © TÜBİTAK doi: Research Article The effect of survivin gene promoter polymorphism on breast cancer 1 1, 1 2 3 Mehmet Deniz ALTIPARMAK , Celal İsmail BİLGİÇ *, Nüzhet Cenap DENER , Esra GÜNDÜZ , Sibel YENİDÜNYA , 2 1 2,4 Muradiye ACAR , Meral ŞEN , Mehmet GÜNDÜZ 1 Department of General Surgery, Faculty of Medicine, Turgut Özal University, Ankara, Turkey 2 Department of Medical Genetics, Faculty of Medicine, Turgut Özal University, Ankara, Turkey 3 Department of Pathology, Faculty of Medicine, Turgut Özal University, Ankara, Turkey 4 Department of Otolaryngology, Faculty of Medicine, Turgut Özal University, Ankara, Turkey Received: Accepted: Published Online: Printed: Abstract: Breast cancer is the most common malignant tumor in women and accounts for about 25% of all cancer diagnoses. Survivin is a member of the apoptosis inhibitor protein family of antiapoptotic proteins. In our study, we investigated one of those, the survivin gene promoter 31G/C polymorphism. Included in this study were 111 breast cancer patients who were operated on in our hospital and 101 healthy female subjects. Blood samples from the healthy subjects and paraffin-embedded tissue samples from the patients were used for DNA extraction and subsequent genetic analysis. PCR-RFLP was used for genotype analysis. We established the clinicopathologic characteristics of patients. No significant difference was found between survivin 31G/C promoter polymorphism of tumor characteristics and breast cancer. Between the control and breast cancer groups, survivin promoter polymorphism 31G/C differences were not significantly different (P = ). The risk of developing cancer, having the relevant GC or CC genotype, is times higher than those having genotype GG (95% confidence interval: to ). Carrying the C allele was .
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