TAILIEUCHUNG - Current paradigms of cancer chemoprevention

Cancer chemoprevention has been continually evolving ever since the term was coined in the 70s. From the original approaches of identifying chemopreventive agents from the dietary constituents based on the epidemiological data to the current status of adapting them from the molecular targets, significant understanding of cancer as a disease and its possible prevention has been achieved. | Turkish Journal of Biology Review Article Turk J Biol (2014) 38: 839-847 © TÜBİTAK doi: Current paradigms of cancer chemoprevention Rajendra G. MEHTA* Cancer Biology Division, IIT Research Institute, Department of Biological and Chemical Sciences, Illinois Institute of Technology, Chicago, Illinois, USA Received: Accepted: Published Online: Printed: Abstract: Cancer chemoprevention has been continually evolving ever since the term was coined in the 70s. From the original approaches of identifying chemopreventive agents from the dietary constituents based on the epidemiological data to the current status of adapting them from the molecular targets, significant understanding of cancer as a disease and its possible prevention has been achieved. The identification of the chemopreventive agent from a complex mixture of natural product extracts involves numerous steps including bioassay guided fractionation; evaluation of the extracts, fractions and isolated new chemicals selectively using in vitro and in vivo experimental models; and understanding the mechanism of their action. This in turn provides identification of the molecular target for the parent drug and a basis for the synthesis of more effective, nontoxic analogs. A chemopreventive agent by definition needs to be nontoxic, since it is expected to be consumed by healthy people that may be at a higher risk of developing cancer. This makes a case for these agents to be evaluated as possible adjuvant chemotherapeutic agents. It is expected that more selective delivery methods to the target organs to eliminate toxicity and use of chemopreventive agents as adjuvant chemotherapeutic agent using personalized approaches will be the next steps for chemoprevention. Key words: Chemoprevention, biomarkers, prevention trials, discovery of chemopreventive agents 1. Introduction It is true that the enormous effort .

• Sinh học
• Prevention trials
• Current paradigms
• Cancer chemoprevention
• Discovery of chemopreventive agents
• Epidemiological data
• BMC Cancer
• Colorectal cancer
• Tertiary prevention
• Cardiovascular prevention trials
• Including inhibition
• Distant metastases
• BMC Anesthesiology
• Meta analysis
• Perioperative shivering
• Randomized controlled trials
• Oxygen consumption
• BMC Pediatrics
• β blockers
• Primary prevention
• Anthracycline therapy
• Heart failure
• Alleviative cardiomyocyte injury
• BMC Musculoskeletal Disorders
• Secondary prevention
• Conservative treatment
• Osteoporotic fracture
• trình bày báo cáo
• tài liệu báo cáo khoa học
• nghiên cứu y học
• báo cáo y học
• kiến thức y học
• công trình y học
• Systematic review
• Low back pain
• Foot orthoses
• Moderate methodological quality
• Clinical trial
• Postoperative nausea and vomiting
• Selective outcome reporting
• Trial registration
• Catheter related bloodstream infection
• Ethanol lock
• Tunneled central venous catheters
• Metabolic abnormality
• Laparoscopic surgery
• Cancer chemotherapy
• Radiation induced skin reactions
• Radiation dermatitis