TAILIEUCHUNG - Comparison of the osteogenic differentiation capacity of adipose tissue derived mesenchymal stem cells from humans and rats
Mesenchymal stem cells (MSCs) can be found in many types of adult tissues such as the bone marrow, adipose, placenta, liver, and periosteum. Recently, adipose tissue-derived MSCs (ADMSCs) have become one the most preferred MSC types because of their fast proliferation rate, abundance, and high plasticity for variable cell types. | Turkish Journal of Biology Research Article Turk J Biol (2016) 40: 1090-1095 © TÜBİTAK doi: Comparison of the osteogenic differentiation capacity of adipose tissue derived mesenchymal stem cells from humans and rats 1, 2, , 2 3 Seçil ERDEN TAYHAN *, Şeyma TAŞDEMİR * **, Saime İsmet DELİLOĞLU GÜRHAN , Erol MİR Department of Bioengineering, Faculty of Engineering and Natural Sciences, Gaziosmanpaşa University, Tokat, Turkey 2 Department of Bioengineering, Faculty of Engineering, Ege University, İzmir, Turkey 3 Department of Pediatric Surgery, Faculty of Medicine, Celal Bayar University, Manisa, Turkey 1 Received: Accepted/Published Online: Final Version: Abstract: Mesenchymal stem cells (MSCs) can be found in many types of adult tissues such as the bone marrow, adipose, placenta, liver, and periosteum. Recently, adipose tissue-derived MSCs (ADMSCs) have become one the most preferred MSC types because of their fast proliferation rate, abundance, and high plasticity for variable cell types. It is known that ADMSCs are able to differentiate into various cells, including osteoblasts, so they are quite promising for orthopedic clinical trials. The present study aimed to compare the osteogenic differentiation conditions of MSCs from human adipose tissue (hADMSC) and those of MSCs from rat adipose tissue (rADMSC). Therefore, differentiation experiments with five different media and two (human and rat) ADMSC types were performed and the mineralization responses of hADMSCs and rADMSCs were different. Key words: Osteogenic differentiation, mesenchymal stem cell, adipose tissue, human, rat 1. Introduction Many people of all ages all over the world suffer from serious bone diseases such as bone fractures, bone tumors, and osteoporosis. The limited treatment options for these disorders indicate a need for new therapies. Cellular therapy is one of the promising methods in .
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