TAILIEUCHUNG - Characterization of cytochalasins and steroids from the fruiting bodies of daldinia concentrica in Viet Nam
[11]-cytochalasa-6(12),13-diene-1,21-dione-7,18,19-trihydroxy-16,18-dimethyl-10-phenyl- (7S*,13E,16S*,18S*,19R*) (1), [11]-cytochalasa-6(12),13-diene-1,21-dione-7,18-dihydroxy16,18-dimethyl-10-phenyl-(7S*,13E,16S*,18R*) (2), ergosterol (3) and ergosterol peroxide (4) were isolated from the methanolic extract of the fruit body of Daldinia concentrica. The structures of these compounds were elucidated using a combination of UV, IR, 1D and 2D NMR techniques (1H-, 13C-NMR, COSY, HSQC and HMBC) and MS analyses. | Vietnam Journal of Science and Technology 56 (4A) (2018) 83-88 CHARACTERIZATION OF CYTOCHALASINS AND STEROIDS FROM THE FRUITING BODIES OF Daldinia concentrica IN VIET NAM Hoang Van Trung1, Nguyen Thi Bich Ngoc2, Nguyen Ngoc Tuan3, Nguyen Tan Thanh1, Tran Dinh Thang1, * 1 School of Chemistry, Biology and Enviroment, Vinh University, 182 Le Duan str., Vinh City, Nghe An province 2 School of Natural Sciences Education, Vinh University, 182 Le Duan str., Vinh City, Nghe An province 3 Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City, 12 Nguyen Van Bao str., Ward 4, Go Vap dist., Ho Chi Minh City * Email: thangtd@ Received: 8 August 2018; Accepted for publication: 10 October 2018 ABSTRACT [11]-cytochalasa-6(12),13-diene-1,21-dione-7,18,19-trihydroxy-16,18-dimethyl-10-phenyl(7S*,13E,16S*,18S*,19R*) (1), [11]-cytochalasa-6(12),13-diene-1,21-dione-7,18-dihydroxy16,18-dimethyl-10-phenyl-(7S*,13E,16S*,18R*) (2), ergosterol (3) and ergosterol peroxide (4) were isolated from the methanolic extract of the fruit body of Daldinia concentrica. The structures of these compounds were elucidated using a combination of UV, IR, 1D and 2D NMR techniques (1H-, 13C-NMR, COSY, HSQC and HMBC) and MS analyses. Keywords: Daldinia concentrica, Xylariaceae, cytochalasin, ergosterol, ergosterol peroxide. 1. INTRODUCTION Daldinia is a genus of fungi and an inedible wood-rotting fungus in the family Xylariaceae. There are more than 80 species, but only 25 species have medicinal value. However, the ascomycete genus Daldinia (Xylariaceae) have been shown to be a good medicinal fungi of unique bioactive secondary metabolites [1]. During more recent studies on the chemical constituents of genus Daldinia more than 20 novel compounds have been discovered, including cytochalasins, aromatic steroids, terpenoids, polyketides, lactones, azaphilone derivatives, benzophone, benzoquinones, binaphthyl derivatives etc. [2-5]. The compounds .
đang nạp các trang xem trước
