TAILIEUCHUNG - Evaluation of the hypoglycemic and hypolipidemic activity of Butea monosperma fruit in diabetic human subjects

Evaluation of the hypoglycemic activity of local Butea monosperma (Palas papra) fruit in normal and diabetic human volunteers was conducted. Sampling was accomplished in and around the city of Faisalabad, especially at the Khadija Mahmood Trust Hospital and at the University of Agriculture, Faisalabad, Pakistan. | Turk J Biol 34 (2010) 189-197 © TÜBİTAK doi: Evaluation of the hypoglycemic and hypolipidemic activity of Butea monosperma fruit in diabetic human subjects Fizza NAEEM1, Sohail Hassan KHAN2 1Department of Home Economics, Division of Education and Extension, University of Agriculture, Faisalabad - PAKISTAN 2Institute of Animal Nutrition and Food Technology, University of Agriculture, Faisalabad - PAKISTAN Received: Abstract: Evaluation of the hypoglycemic activity of local Butea monosperma (Palas papra) fruit in normal and diabetic human volunteers was conducted. Sampling was accomplished in and around the city of Faisalabad, especially at the Khadija Mahmood Trust Hospital and at the University of Agriculture, Faisalabad, Pakistan. Volunteers were categorized into normal and diabetic subjects on the basis of their blood glucose levels. Male and female diabetic volunteers aged between 30 and 60 years participated in the study. All the diabetic volunteers suffered from diabetes type II, . noninsulin-dependent diabetes mellitus (NIDDM). The subjects were divided into 5 groups as follows: Group A - Untreated normal subjects; Group B - Normal subjects who received powdered B. monosperma (3 g) in 30 mL of water for 30 days, orally; Group C - Control diabetic subjects; Group D - Diabetic subjects who received powdered (3 g) in 30 mL of water for 30 days, orally; and Group E - Diabetic subjects who received a 5-mg tablet b. I. d. of Daonil® (a standard oral antidiabetic drug) in 30 mL of water for 30 days. The oral administration of B. monosperma fruit to diabetic and normal subjects for 30 days decreased (P < ) blood glucose, urine sugar, and plasma glycoprotein levels, as well as the lipid profile and the activity of liver enzymes. In conclusion, the powder of the medicinal plant B. monosperma fruit can be considered an effective and alternative treatment for diabetes. Key words: Butea monosperma fruit, glucose level, diabetic .

• Sinh học
• Butea monosperma fruit
• Glucose level
• Diabetic human volunteers
• Hypolipidemic activity
• Butea monosperma fruit
• Non insulin dependent diabetes mellitus