TAILIEUCHUNG - Two cycloartanes-type triterpenoid from Homonoia riparia Lour
Using various chromatography methods, two known cycloartanes, 24-methylenecycloartane-3β,6β,7β,16β-tetraol (1) and riparsaponin (2), together with two known flavonol glycosides, quercetin 3-O-β-D-glucopyranoside (3) and quercetin 3-O-α-L-rhamnopyranosyl (1→6) β-D-glucopyranoside (4) were isolated from the methanol extract of the leaves of Homonoia riparia Lour. Their structures were determined by MS and 1D-, 2D-NMR spectra, as well as by comparison with those reported in the literature. | Vietnam Journal of Chemistry, International Edition, 55(4): 494-498, 2017 DOI: Two cycloartanes-type triterpenoid from Homonoia riparia Lour Le Thi Huyen1, Nguyen Thi Son1, Phan Van Kiem2* 1 University of Science, Vietnam National University (VNU) 2 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) Received 3 June 2017; Accepted for publication 28 August 2017 Abstract Using various chromatography methods, two known cycloartanes, 24-methylenecycloartane-3β,6β,7β,16β-tetraol (1) and riparsaponin (2), together with two known flavonol glycosides, quercetin 3-O-β-D-glucopyranoside (3) and quercetin 3-O-α-L-rhamnopyranosyl (1→6) β-D-glucopyranoside (4) were isolated from the methanol extract of the leaves of Homonoia riparia Lour. Their structures were determined by MS and 1D-, 2D-NMR spectra, as well as by comparison with those reported in the literature. Keywords. Homonoia riparia, cycloartane, flavonol glycoside. 1. INTRODUCTION Homonoia is a small genus of shrubs which belongs to the Euphorbiaceae family that is widespread from India to mainland China, Taiwan, and Vietnam, and found commonly at riverbanks [1]. The plant is used for the treatment of various diseases such as hepatitis, pneumonia, scald, and skin diseases [1, 2]. The phytochemical studies of H. riparia confirmed the presence of sterols, triterpenes, and flavonoids [3, 4]. In this paper, we report herein the isolation and structure elucidation of two cycloartane-type triterpenoids and two flavonol glycosides from the methanol extract of the H. riparia leaves. 2. MATERIAL AND METHODS . Plant materials The leaves of H. riparia collected in Vinhphuc, Vietnam, in March 2016, and identified by Prof. Ninh Khac Ban, Institute of Marine Biochemistry, Vietnam Academy of Science and Technology. A voucher specimen (HR01) was deposited at Lab of Pharmaceutical Chemistry, Faculty of Chemistry, University of Science, VNU. . General experimental
đang nạp các trang xem trước
