TAILIEUCHUNG - báo cáo khoa học: "Cationic nanoparticles for delivery of amphotericin B: preparation, characterization and activity in vitro"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Cationic nanoparticles for delivery of amphotericin B: preparation, characterization and activity in vitro | Journal of Nanobiotechnology BioMed Central Research Open Access Cationic nanoparticles for delivery of amphotericin B preparation characterization and activity in vitro Débora B Vieira and Ana M Carmona-Ribeiro Address Departamento de Bioquímica Instituto de Química Universidade de São Paulo CP 26077 CEP 05513-970 São Paulo Brazil Email Débora B Vieira - deborabv@ Ana M Carmona-Ribeiro - mcribeir@ Corresponding author Published 7 May 2008 Received 31 January 2008 Journal of Nanobiotechnology 2008 6 6 doi 1477-3 155-6-6 Accepted 7 May 2008 This article is available from http content 6 1 6 2008 Vieira and Carmona-Ribeiro licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Particulate systems are well known to be able to deliver drugs with high efficiency and fewer adverse side effects possibly by endocytosis of the drug carriers. On the other hand cationic compounds and assemblies exhibit a general antimicrobial action. In this work cationic nanoparticles built from drug cationic lipid and polyelectrolytes are shown to be excellent and active carriers of amphotericin B against C. albicans. Results Assemblies of amphotericin B and cationic lipid at extreme drug to lipid molar ratios were wrapped by polyelectrolytes forming cationic nanoparticles of high colloid stability and fungicidal activity against Candida albicans. Experimental strategy involved dynamic light scattering for particle sizing zeta-potential analysis colloid stability determination of AmB aggregation state by optical spectra and determination of activity against Candida albicans in vitro from cfu countings. Conclusion Novel and effective cationic particles delivered amphotericin B to C. .

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