TAILIEUCHUNG - Journal of Nanobiotechnology: Applications of nanoparticles in biology and medicine

Many people who today choose herbal products in lieu of prescription medications assume that because these products are natural, they must be safe, even when the evidence for this assertion is essentially anecdotal. Recent studies have shown that herbals are highly variable in quality and composition, with many marketed products containing little of the intended ingredients and containing unintended contaminants, such as heavy metals and prescription drugs. A few herbals are banned outright in several countries. Comfrey and kava have been associated with liver failure, aristolochia with genitourinary cancer (De Smet 2002), and ephedra with heart attacks and strokes (Shekelle and others 2003). More important, herbals contain ingredients that can accelerate or. | Journal of Nanobiotechnology BioMed Central Review Applications of nanoparticles in biology and medicine OV Salata Open Access Address Sir William Dunn School of Pathology University of Oxford South Parks Road Oxford OX1 3RE UK Email OV Salata - Corresponding author Published 30 April 2004 Received 23 December 2003 Accepted 30 April 2004 Journal of Nanobiotechnology 2004 2 3 This article is available from http content 2 1 3 2004 Salata licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Nanomaterials are at the leading edge of the rapidly developing field of nanotechnology. Their unique size-dependent properties make these materials superior and indispensable in many areas of human activity. This brief review tries to summarise the most recent developments in the field of applied nanomaterials in particular their application in biology and medicine and discusses their commercialisation prospects. Introduction Nanotechnology 1 is enabling technology that deals with nano-meter sized objects. It is expected that nanotechnology will be developed at several levels materials devices and systems. The nanomaterials level is the most advanced at present both in scientific knowledge and in commercial applications. A decade ago nanoparticles were studied because of their size-dependent physical and chemical properties 2 . Now they have entered a commercial exploration period 3 4 . Living organisms are built of cells that are typically 10 pm across. However the cell parts are much smaller and are in the sub-micron size domain. Even smaller are the proteins with a typical size of just 5 nm which is comparable with the dimensions of smallest manmade nanoparticles. This simple size comparison gives an idea of using nanoparticles as very small .

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