TAILIEUCHUNG - Báo cáo khoa hoc:"Muscle-related traits in cattle: The role of the myostatin gene in the South Devon breed"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Muscle-related traits in cattle: The role of the myostatin gene in the South Devon breed | 221 Genet. Sel. Evol. 34 2002 221-232 INRA EDP Sciences 2002 DOI gse 2002005 Original article Muscle-related traits in cattle The role of the myostatin gene in the South Devon breed Pamela Wiener Judith Alexis Smith Alyson Margaret Lewis John Arthur Woolliams John Lewis Williams Roslin Institute Roslin Midlothian EH25 9PS UK Received 22 February 2001 accepted 19 October 2001 Abstract - In this paper we examined the effects of an 11-bp mutation within the GDF-8 gene originally identified in Belgian Blue cattle in the South Devon breed. The mutation was found at moderate frequency in the South Devon population. We quantified the effects of this mutation on growth body composition and calving traits in South Devon cattle. We found that the mutation significantly increased muscle score and calving difficulty and decreased fat depth. The mutation did not significantly affect weight at 200 and 400 days or muscle depth. its effect on muscle score and fat depth was additive while its effect on calving difficulty was recessive. The mutation accounted for a significant proportion of the phenotypic variance in muscle score and calving difficulty. There was an economic benefit of the mutation for this data set however calculations were sensitive to changes in the parameter values. Additional data would be required to refine these calculations. GDI -8 myostatin South Devon cattle double muscling muscle hypertrophy 1. INTRODUCTION Identification of the myostatin gene GDF-8 has been one of the most important findings in cattle genetics of the last decade since it represents the first gene to have been identified with a large effect on an economically important trait. Variation in this gene first discovered in mice 16 and then identified in cattle 10 has been shown to explain large phenotypic Correspondence and reprints E-mail Present address Department of Veterinary Parasitology University of Glasgow Bearsdon Road Glasgow G61 1Qh UK. Present .

• Báo cáo khoa học
• Báo cáo sinh học hay
• cách trình bày báo cáo
• báo cáo sinh học
• công trình nghiên cứu sinh học
• tài liệu về sinh học