TAILIEUCHUNG - Báo cáo khoa học: "Pim-1 A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Pim-1 A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis" | J. Vet. Sá. 2001 2 3 167-179 I Veterinary Science Pim-1 A serine threonine kinase with a role in cell survival proliferation differentiation and tumorigenesLS Zeping Wang Nandini Bhattacharya Matt Weaver Kate Petersen Maria Meyer Leslie Gapter and Nancy s. Magnuson School of Molecular Biosciences Washington State University Pullman Washington 99164-4234 Abstract Pim-1 belongs to a family of serini threonine protein kinases that are highly conserved through evolution in multicellular organisms. Originally identified from Moloney murine leukemia virus MuLV -induced T-cell lymphomas in mice Pim-1 kinase is involved in the control of cell growth differentiation and apoptosis. Expression of Pun-1 kinase can be stimulated by a variety of growth factors and regulated at four different levels transcriptional post-transcriptional translational and post-translational. Several signal transduction pathways may be associated with the regulation of Pim-l s expression accumulating data support that the expression of Pim-1 protein is mediated through activation of JAIVSTATs. Recent studies of Pirn family kinases indicate that Hm-1 kinase plays important roles outside of the hematopoietic system as well. Key words oncogene Pim-1 kinase differentiation apoptosis tumorigenesis proliferation cell survival signal transduction Introduction The pim-1 gene was originally discovered as a preferential site for proviral integration of the moloney murine leukemia virus MuLV in mice 14 96 . The integration region was designated pim-1 for proviral integration site for MuLV. Since the original report of the cloning of murine pim-1 proto-oncogene 97 Pim-1 cDNAs of human bovine rat frog and zebrafish have also been cloned Corresponding author Telephone 5C9-335-0966 Fax 509-335-1907 e-mail magnuson@ 20 64 82 86 111 116 . Hie pim-1 gene codes for a highly conserved serinq threonine kinase whose expression is not only stimulated by a variety of cytokines hormones and mitogens but is also

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.