TAILIEUCHUNG - Báo cáo sinh học: " Individual increase in inbreeding allows estimating effective sizes from pedigrees"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học thế giới đề tài: Individual increase in inbreeding allows estimating effective sizes from pedigrees | Genet. Sel. Evol. 40 2008 359-378 INRA EDP Sciences 2008 DOI gse 2008008 Available online at Original article Individual increase in inbreeding allows estimating effective sizes from pedigrees Juan Pablo Gutierrez1 Isabel Cervantes1 Antonio Molina2 Mercedes Valera3 Felix Goyache4 1Departamento de Produccion Animal Facultad de Veterinaria Avda. Puerta de Hierro s n 28040 Madrid Spain 2Departamento de Genetica Universidad de Cordoba Ctra. Madrid-Cadiz km 396a 14071 Cordoba Spain 3Departamento de Ciencias Agro-Forestales EUITA Universidad de Sevilla Ctra. Utrera km 1 41013 Sevilla Spain 4SERIDA-Somio C Camino de los Claveles 604 33203 Gijon Asturias Spain Received 14 May 2007 accepted 9 January 2008 Abstract - We present here a simple approach to obtain reliable estimates of the effective population size in real world populations via the computation of the increase in inbreeding for each individual delta Fj in a given population. The values of delta Fl are computed as t-root of 1 1 Fj where Fj is the inbreeding coefficient and t is the equivalent complete generations for each individual. The values of delta F computed for a pre-defined reference subset can be averaged and used to estimate effective size. A standard error of this estimate of Ne can be further computed from the standard deviation of the individual increase in inbreeding. The methodology is demonstrated by applying it to several simulated examples and to a real pedigree in which other methodologies fail when considering reference subpopulations. The main characteristics of the approach and its possible use are discussed both for predictive purposes and for analyzing genealogies. effective size increase in inbreeding overlapped generation genetic contribution 1. INTRODUCTION The effective population size Ne defined as the size of an idealized population which would give rise to the rate of inbreeding or the rate of change in variance of gene frequencies observed in the .

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